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Studies on the Treatment of Leprosy with a Synthesized Thiocarbanilide Derivative L-4

Lew J, Cllang CH, Choi TK

A total of 62 leprosy patients, 47 lepromatous type, 9 tuberculoid, 5 borderline group and 1 indeterminate group, have been treated with a synthesized thiocarbanilide L-4, and the effectiveness of...
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A case of hyperosmolar nonketotic coma associated with androgen deprivation therapy in prostate cancer

Hong EY, Lee SW, Kang JG, Kim CS, Ihm SH, Yoo HJ, Lee SJ

  • KMID: 1458438
  • Korean J Med.
  • 2010 Nov;79(5):573-576.
During advanced prostate cancer, androgen deprivation therapy (ADT) using gonadotropin-releasing hormone and antiandrogen is an effective treatment modality. Recently, it has been reported that ADT may result in diabetes mellitus...
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Differential Expression of RANKL and OPG by the PPAR gamma Agonist Rosiglitazone in Osteoblasts

Lee MJ, Lee SY, Park SH, Ahn DW

  • KMID: 2189021
  • J Korean Soc Osteoporos.
  • 2010 Apr;8(1):47-55.
OBJECTIVES: Osteoblasts secrete receptor activator of nuclear factor-kB ligand (RANKL) and osteoprotegerin (OPG). RANKL stimulates osteoclastogenesis but OPG inhibits it by binding with RANKL. Although peroxisome proliferation-activated receptor gamma (PPARgamma)...
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Bicalutamide-induced Interstitial Lung Disease

Kim YK, Kim YH, Lee JJ, Choi CW, Yoo JH, Park MJ, Kang HM

  • KMID: 2319311
  • Tuberc Respir Dis.
  • 2010 Apr;68(4):226-230.
Androgen deprivation therapy, which is the standard treatment for metastatic prostate cancer, includes nonsteroidal antiandrogenic drugs, such as flutamide, nilutamide and bicalutamide. Of them, bicalutamide rarely induces interstitial pneumonia. We...
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Duration and Magnitude of Extracellular Signal-Regulated Protein Kinase Phosphorylation Determine Adipogenesis or Osteogenesis in Human Bone Marrow-Derived Stem Cells

Jung HS, Kim YH, Lee JW

PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during...
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Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes

An S, Jang YS, Park JS, Kwon BM, Paik YK, Jeong TS

We investigated the mechanism of spontaneous cholesterol efflux induced by acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition, and how an alteration of cholesterol metabolism in macrophages impacts on that in HepG2 cells....
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