- KR-31831, a new synthetic anti-ischemic agent, inhibits in vivo and in vitro angiogenesis
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Yi EY, Park SY, Song HS, Son MJ, Yi KY, Yoo SE, Kim YJ
- KMID: 1098084
- Exp Mol Med.
- 2006 Oct;38(5):502-508.
Angiogenesis is considered to be an integral process to the growth and spread of solid tumors. Anti-angiogenesis therapy recently has been found to be one of the most promising anti-cancer... -
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- 5-Formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway
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Zhu W, Fu A, Hu J, Wang T, Luo Y, Peng M, Ma Y, Wei Y, Chen L
- KMID: 1109403
- Exp Mol Med.
- 2011 Mar;43(3):146-152.
- doi: 10.3858/emm.2011.43.3.017
Our previous report has demonstrated that 5-formylhonokiol (FH), a derivative of honokiol (HK), exerts more potent anti-proliferative activities than honokiol in several tumor cell lines. In present study, we first... -
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- Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1
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Kang JH, Kim SA, Chang SY, Hong S, Hong KJ
- KMID: 1047092
- Exp Mol Med.
- 2007 Jun;39(3):402-411.
Expression of thrombospondin-1 (TSP-1), which is a known inhibitor of tumor growth and angiogenesis, is reciprocally regulated by positive regulators, such as VEGF. Additionally, trichostatin A (TSA) suppresses tumor progression... -
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- Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo
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Kim EC, Kim SH, Piao SJ, Kim TJ, Bae K, Kim HS, Hong SS, Lee BI, Nam M
- KMID: 2164486
- J Korean Med Sci.
- 2015 Jul;30(7):979-987.
- doi: 10.3346/jkms.2015.30.7.979
Angiogenesis, the formation of new blood vessels, is critical for tumor growth and metastasis. Notably, tumors themselves can lead to angiogenesis by inducing vascular endothelial growth factor (VEGF), which is... -
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- A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity
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Kim JW, Kim TD, Hong BS, Kim OY, Yoon WH, Chae CB, Gho YS
- KMID: 1104211
- Exp Mol Med.
- 2010 Jul;42(7):514-523.
- doi: 10.3858/emm.2010.42.7.052
Angiogenesis is critical and indispensable for tumor progression. Since VEGF is known to play a central role in angiogenesis, the disruption of VEGF-VEGF receptor system is a promising target for... -
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- Effects of Bevacizumab on Bcl-2 Expression and Apoptosis in Retinal Pigment Epithelial Cells under Oxidative Stress
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Kim S, Kim YJ, Kim NR, Chin HS
- KMID: 2363851
- Korean J Ophthalmol.
- 2015 Dec;29(6):424-432.
- doi: 10.3341/kjo.2015.29.6.424
PURPOSE: To evaluate the effects of bevacizumab on expression of B-cell leukemia/lymphoma (Bcl)-2 and apoptosis in retinal pigment epithelial (RPE) cells under oxidative stress conditions. METHODS: RPE cells were treated with... -
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- Evaluation of Antiangiogenic Effects of a New Synthetic Candidate Drug KR-31831 on Xenografted Ovarian Carcinoma Using Dynamic Contrast Enhanced MRI
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Yang J, Kim JH, Im GH, Heo H, Yoon S, Lee J, Lee JH, Jeon P
- KMID: 1116446
- Korean J Radiol.
- 2011 Oct;12(5):602-610.
- doi: 10.3348/kjr.2011.12.5.602
OBJECTIVE: The purpose of this research was to investigate the anti-angiogenic inhibitory effect of KR-31831, a newly developed anti-angiogenic agent, on an in vivo human ovarian carcinoma model using dynamic... -
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