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A New Synthesis of TE2A-a Potential Bifunctional Chelator for (64)Cu

Pandya DN, Kim JY, Kwak W, Park JC, Gawande MB, An GI, Ryu EK, Yoo J

  • KMID: 1455394
  • Nucl Med Mol Imaging.
  • 2010 Sep;44(3):185-192.
PURPOSE: The development of a new bifunctional chelator, which holds radiometals strongly in living systems, is a prerequisite for the successful application of disease-specific biomolecules to medical diagnosis and therapy....
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The Synthesis of the Stable IVDU Derivative for Imaging HSV-1 TK Expression

Kim EJ, Choi TH, Ahn SH, Kim BS, Park H, Cheon GJ, Rhee HJ, An GI

  • KMID: 1841153
  • Nucl Med Mol Imaging.
  • 2009 Oct;43(5):478-486.
PURPOSE: 5-iododeoxyuridine analogues have been exclusively developed for the potential antiviral and antitumor therapeutic agents. In this study, we synthesized carbocyclic radioiododeoxyuridineanalogue (ddIVDU) and carbocyclic intermediate as efficient carbocyclic radiopharmaceuticals. MATERIALS...
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Production of [18F]F2 Gas for Electrophilic Substitution Reaction

Moon BS, Kim JH, Lee KC, An GI, Cheon GJ, Chun KS

  • KMID: 1512534
  • Nucl Med Mol Imaging.
  • 2006 Aug;40(4):228-232.
PURPOSE: Electrophilic 18F (T1/2=110 min) radionuclide in the form of [18F]F2 gas is of great significance for labeling radiopharmaceuticals for positron emission tomography (PET). However, its production in high yield...
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Imaging of Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression with Radiolabeled 5-(2-iodovinyl)-2'-deoxyuridine (IVDU) in Liver by Hydrodynamic-based Procedure

Song I, Lee TS, Kang JH, Lee YJ, Kim KI, An GI, Chung WS, Cheon GJ, Choi CW, Lim SM

  • KMID: 1841152
  • Nucl Med Mol Imaging.
  • 2009 Oct;43(5):468-477.
PURPOSE: Hydrodynamic-based procedure is a simple and effective gene delivery method to lead a high gene expression in liver tissue. Non-invasive imaging reporter gene system has been used widely with...
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Facile Fabrication of Animal-Specific Positioning Molds For Multi-modality Molecular Imaging

Park JC, Oh J, Woo S, Kwak W, Lee JE, Kim KM, An GI, Choi TH, Cheon GJ, Chang Y, Lee SW, Ahn BC, Lee J, Yoo J

  • KMID: 2051953
  • Nucl Med Mol Imaging.
  • 2008 Oct;42(5):401-409.
PURPOSE: Recently multi-modal imaging system has become widely adopted in molecular imaging. We tried to fabricate animal-specific positioning molds for PET/MR fusion imaging using easily available molding clay and rapid...
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A Study on Preparation of 3'-[18F]Fluoro-3'-deoxythymidine and Its Biodistribution in 9L Glioma Bearing Rats

Shim AY, Moon BS, Lee TS, Lee KC, An GI, Yang SD, Yu KH, Cheon GJ, Choi CW, Lim SM, Chun KS

  • KMID: 1512526
  • Nucl Med Mol Imaging.
  • 2006 Oct;40(5):263-270.
PURPOSE: Several radioisotope-labeled thymidine derivatives such as [11C]thymidine was developed to demonstrate cell proliferation in tumor. But it is difficult to track metabolism with [11C]thymidine due to rapid in vivo...
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Synthesis and Preliminary Evaluation of 9-(4-[18F]Fluoro-3-hydroxymethylbutyl) Guanine ([18F]FHBG) in HSV1-tk Gene Transduced Hepatoma Cell

Moon BS, Lee TS, Lee MK, Lee KC, An GI, Chun KS, Awh OD, Chi DY, Choi CW, Lim SM, Cheon GJ

  • KMID: 1512533
  • Nucl Med Mol Imaging.
  • 2006 Aug;40(4):218-227.
PURPOSE: The HSV1-tk reporter gene system is the most widely used system because of its advantage that direct monitoring is possible without the introduction of a separate reporter gene in...
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Effectiveness of [124I]-PET/CT and [18F]-FDG-PET/CT for Localizing Recurrence in Patients with Differentiated Thyroid Carcinoma

Lee J, Nah KY, Kim RM, Oh YJ, An YS, Yoon JK, An GI, Choi TH, Cheon GJ, Soh EY, Chung WY

Although the prognosis of patients with differentiated thyroid carcinoma (DTC) is generally encouraging, a diagnostic dilemma is posed when an increasing level of serum thyroglobulin (Tg) is noted, without detection...
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