- The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus
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Jang YH, Min DS
- KMID: 1506220
- Exp Mol Med.
- 2012 Oct;44(10):571-577.
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. PLD is localized in most cellular organelles, where it is likely to play different... -
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- Genotypic Variations among Human Calciviruses in Korea: 1987-1994
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Nam KB, Kim JA, Kim KH, Yang JM
- KMID: 1541346
- J Korean Soc Virol.
- 1997 Dec;27(2):185-196.
Sequence comparison of the RNA-dependent RNA polymerase of human caliciviruses (HuCVs) from Korean children with gastroenteritis revealed significant genetic variation among them. cDNA clones were produced from the HuCVs collected... -
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- Antigenic and immunogenic investigation of the virulence motif of the Newcastle disease virus fusion protein
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Choi KS, Lee EK, Jeon WJ, Kwon JH
- KMID: 1093494
- J Vet Sci.
- 2010 Sep;11(3):205-211.
- doi: 10.4142/jvs.2010.11.3.205
Newcastle disease (ND) caused by virulent Newcastle disease virus (NDV) is a highly contagious viral disease of poultry. Virulent NDVs characteristically have a multibasic amino acid sequence (virulence motif) such... -
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- RNA polymerase II carboxy-terminal domain with multiple connections
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Cho EJ
- KMID: 1047075
- Exp Mol Med.
- 2007 Jun;39(3):247-254.
The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of... -
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- Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif
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Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J
- KMID: 1094661
- Exp Mol Med.
- 2007 Apr;39(2):205-212.
Checkpoint kinase 1 (Chk1) and Chk2 are effector kinases in the cellular DNA damage response and impairment of their function is closely related to tumorigenesis. Previous studies revealed several substrate... -
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- The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity
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Nam MK, Seong YM, Park HJ, Choi JY, Kang S, Rhim H
- KMID: 1105275
- Exp Mol Med.
- 2006 Feb;38(1):36-43.
Serine protease activity of high temperature requrement 2 (HtrA2) is essential for promoting cell death, as well as for protecting against cellular stresses. An X-ray crystallographic study described the formation... -
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- Characterization of yeast deoxyhypusine synthase: PKC-dependent phosphorylation in vitro and functional domain identification
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Kang KR, Chung SI
- KMID: 1029929
- Exp Mol Med.
- 1999 Dec;31(4):210-216.
The biosynthesis of hypusine [Nepsilon-(4-amino-2-hydroxybutyl)-lysine] occurs in the eIF-5A precursor protein through two step posttranslational modification involving deoxyhypusine synthase which catalyzes transfer of the butylamine moiety of... -
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- Norwalk-Like Viruses, A Common Cause of Sporadic Acute Gastroenteritis in korean Children
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Kim KH, Xiang X
- KMID: 1943466
- J Korean Soc Microbiol.
- 1997 Apr;32(2):227-236.
Norwalk-like virus (NLV), one of the emerging enteric pathogens in sporadic cases and outbreaks of acute gastroenteritis (AG) worldwide, are 30-35 nm in diameter and have a single stranded RNA... -
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- The centrosomal localization of KM-HN-1 (MGC33607) depends on the leucine zipper motif and the C-terminal coiled-coil domain
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Park HJ, Seo HJ, Kim HW, Kim JS, Hwang SY, Seong YS
- KMID: 1091078
- Exp Mol Med.
- 2007 Dec;39(6):828-838.
KM-HN-1 is a C-terminal coiled-coil domain containing protein previously referred to as image clone MGC33607. This protein has been previously identified as a cancer/testis antigen and reported as nuclear and... -
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- Recombinant tetra-cell adhesion motifs supports adhesion, migration and proliferation of keratinocytes/fibroblasts, and promotes wound healing
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Jung MY, Thapa N, Kim JE, Yang JD, Cho BC, Kim IS
- KMID: 1090969
- Exp Mol Med.
- 2007 Oct;39(5):663-672.
An extracellular matrix protein plays an important role in skin wound healing. In the present study, we engineered a recombinant protein encompassing the 9th and 10th type III domains of... -
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- betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin
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Lee BH, Bae JS, Park RW, Kim JE, Park JY, Kim IS
- KMID: 1111408
- Exp Mol Med.
- 2006 Apr;38(2):153-161.
Adhesion and migration of vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of atherosclerosis. These processes involve the interaction of VSMCs with extracellular matrix proteins. Here,... -
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- Beta ig-h3 promotes renal proximal tubular epithelial cell adhesion, migration and proliferation through the interaction with alpha3beta1 integrin
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Park SW, Bae JS, Kim KS, Park SH, Lee BH, Choi JY, Park JY, Ha SW, Kim YL, Kwon TH, Kim IS, Park RW
- KMID: 1097102
- Exp Mol Med.
- 2004 Jun;36(3):211-219.
Betaig-h3 (betaig-h3) is a secretory protein composed of fasciclin I-like repeats containing sequences that allows binding of integrins and glycosaminoglycans in vivo. Expression of betaig-h3 is responsive to TGF-beta and... -
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- Identification of Two Novel NPM1 Mutations in Patients with Acute Myeloid Leukemia
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Jeon Y, Seo SW, Park S, Park S, Kim SY, Ra EK, Park SS, Seong MW
- KMID: 1781299
- Ann Lab Med.
- 2013 Jan;33(1):60-64.
- doi: 10.3343/alm.2013.33.1.60
BACKGROUND: Genetic abnormalities in adult AML are caused most frequently by somatic mutations in exon 12 of the NPM1 gene, which is observed in approximately 35% of AML patients and... -
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- Clinical and Virologic Characteristics of Lamivudine Resistance in HBV-associated Chronic Liver Disease
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Kim SS, Chung MG, Ju KT, Park DK, Kwon OS, Koo YS, Kim YK, Choi DJ, Hwang YJ, Kim JH
- KMID: 863116
- Korean J Hepatol.
- 2002 Dec;8(4):405-417.
BACKGROUND/AIMS: Lamivudine therapy in chronic hepatitis B has been shown to be effective in inhibiting HBV replication. However, lamivudine resistance has been developed with prolonged use. We studied to... -
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- Detection of YMDD Motif Mutants by Oligonucleotide Chips in Lamivudine-Untreated Patients with Chronic Hepatitis B Virus Infection
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Heo J, Cho M, Kim HH, Shin YM, Jang HJ, Park HK, Kim CM, Kim GH, Kang DH, Song GA, Yang US
- KMID: 2157683
- J Korean Med Sci.
- 2004 Aug;19(4):541-546.
- doi: 10.3346/jkms.2004.19.4.541
Lamivudine, a nucleoside analogue, has been used widely as an effective antiviral agent for the treatment of patients with chronic hepatitis B virus (HBV) infection. However, the YMDD motif mutation... -
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- Viral Breakthrough in HBeAg-Negative Chronic Hepatitis B Patients Receiving Lamivudine Therapy
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Chang YJ, Yim JY, Cho NY, Choi CW, Baek SJ, Ahn SH, Choi DW, Kwon YD, Kim SS, Kwon OS, Kim JH, Yeon JE, Song JW, Byun KS, Lee CH
- KMID: 863115
- Korean J Hepatol.
- 2002 Dec;8(4):397-404.
BACKGROUND/AIMS: Long-term efficacy and the rate of viral breakthrough in patients with HBeAg- negative chronic hepatitis B receiving lamivudine therapy is uncertain. This study was conducted to determine the... -
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