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Alterations of epinephrine-induced gluconeogenesis in aging

Kim K, Cho SC, Cova A, Jang IS, Park SC

The effects of glucagon and epinephrine on gluconeogenesis in young (4 month) and old (24 month) Fisher 344 rat hepatocytes were compared. In contrast to glucagon, which had a similar...
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Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner

Lee ME, Kim SR, Lee S, Jung YJ, Choi SS, Kim WJ, Han JA

  • KMID: 1389733
  • Exp Mol Med.
  • 2012 Sep;44(9):536-544.
It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a...
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PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach

Choi YJ, Kim N, Lee JY, Nam RH, Suh JH, Lee SM, Ham MH, Jo HJ, Shim YK, Park YH, Lee JC, Choi YJ, Lee HS, Lee DH

BACKGROUND/AIMS: The aim of this study was to evaluate the effect of the synthetic S-allyl-l-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats. METHODS: The rats...
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