- Cyclin E expression in benign and malignant epithelial neoplasms of the gallbladder
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Jin YM, Yim H, Shim C
- KMID: 699965
- Yonsei Med J.
- 1997 Oct;38(5):301-306.
- doi: 10.3349/ymj.1997.38.5.301
Cyclins are the regulatory subunits of cyclin-dependent kinase and play an important role in cell proliferation. Many tumors, such as colon, breast and gastric carcinomas are known to be involved... -
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- Correlation between expression of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) and angiogenesis in colorectal adenocarcinoma
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Kim TS, Kim YB
- KMID: 646304
- J Korean Med Sci.
- 1999 Jun;14(3):263-270.
- doi: 10.3346/jkms.1999.14.3.263
Matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), which degrade extracellular matrix, are believed to play a crucial role in tumor invasion and metastasis. Angiogenesis is also perceived as an important... -
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- Basal cell adenocarcinoma of the salivary gland--a case report
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Kim KI, Oh HE, Mun JS, Kim CH, Choi JS
- KMID: 1081041
- J Korean Med Sci.
- 1997 Oct;12(5):461-464.
- doi: 10.3346/jkms.1997.12.5.461
Basal cell adenocarcinoma of the salivary gland is a very rare disease entity as the malignant counterpart of basal cell adenoma. On the basis of morphologic pattern, basal cell... -
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- Mucin histochemistry by paradoxical concanavalin A staining in early gastric carcinomas
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Cho KJ, Myong HH, Jang JJ
- KMID: 1421845
- J Korean Med Sci.
- 1991 Jun;6(2):119-125.
- doi: 10.3346/jkms.1991.6.2.119
Phenotypic expression of tumor cells was investigated in 33 early gastric carcinomas by mucin histochemistry using paradoxical concanavalin A staining. This staining method had been developed to differentiate 3 classes... -
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- p21 expression and mutation in gastric carcinoma: analysis by immunohistochemistry and PCR-SSCP
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Park YE, Choi KC, Choi YH
- KMID: 645210
- J Korean Med Sci.
- 1998 Oct;13(5):507-512.
- doi: 10.3346/jkms.1998.13.5.507
p21 protein has been reported to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. Thus, the p21 gene is thought to play a... -
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- Clinicopathologic and Molecular Characteristics of Lung Adenocarcinoma Arising in Young Patients
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Kim L, Kim KH, Yoon YH, Ryu JS, Choi SJ, Park IS, Han JY, Kim JM, Chu YC
- KMID: 1782135
- J Korean Med Sci.
- 2012 Sep;27(9):1027-1036.
- doi: 10.3346/jkms.2012.27.9.1027
Lung cancer rarely occurs in young patients. Recent studies have demonstrated that epidemiologic data are closely correlated to some molecular characteristics. We investigated the clinicopathologic characteristics of lung adenocarcinoma in... -
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- Clinicopathologic characteristics of mucinous gastric adenocarcinoma
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Hyung WJ, Noh SH, Shin DW, Yoo CH, Kim CB, Min JS, Lee KS
- KMID: 711621
- Yonsei Med J.
- 1999 Apr;40(2):99-106.
- doi: 10.3349/ymj.1999.40.2.99
There has been considerable controversy over the prognosis of mucinous gastric enocarcinoma (MGC). In this study we analyzed the clinicopathologic fferences between MGC and non-mucinous gastric carcinoma (NMGC).... -
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- Expression of cyclin dependent kinase inhibitor p21WAF1 alone and in combination with p27KIP1 shows prognostic value in gastric carcinoma
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Jang SJ, Ahn MJ, Paik SS, Kong G, Keum JS, Park YW, Lee JD
- KMID: 1038163
- J Korean Med Sci.
- 1998 Aug;13(4):369-376.
- doi: 10.3346/jkms.1998.13.4.369
Evidence suggests that multiple molecular events, including alteration of cell cycle regulators are involved in the development and progression of gastric carcinoma. Recently, it has been reported that the... -
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- Cyclooxygenase 2 in Gastric Carcinoma Is Expressed in Doublecortin- and CaM Kinase-Like-1-Positive Tuft Cells
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Mutoh H, Sashikawa , Sakamoto H, Tateno T
- KMID: 2070061
- Gut Liver.
- 2014 Sep;8(5):508-518.
- doi: 10.5009/gnl13237
BACKGROUND/AIMS: Doublecortin and CaM kinase-like-1 (DCAMKL1) is a marker of stem cells expressed predominantly in the crypt base in the intestine. However, DCAMKL1-positive cells have been shown to be differentiated... -
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- Differential Expression of Hypoxia Inducible Factor-1 alpha and Tumor Cell Proliferation Between Squamous Cell Carcinomas and Adenocarcinomas Among Operable Non-Small Cell Lung Carcinomas
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Lee CH, Lee MK, Kang CD, Kim YD, Park DY, Kim JY, Sol MY, Suh KS
- KMID: 2157622
- J Korean Med Sci.
- 2003 Apr;18(2):196-203.
- doi: 10.3346/jkms.2003.18.2.196
This study aimed to evaluate whether the elevated level of hypoxia-inducible factor-1 alpha (HIF-1 alpha) correlated with histologic types, angiogenesis, tumor cell proliferation, and clinical parameters in common non-small cell... -
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- Expression of Hedgehog Proteins in Periampullary Cancer
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Lee SY, Lee KT, Jang KT, Choi SH, Heo JS, Kim DH, Lee JK, Paik SW, Rhee JC
- KMID: 772846
- Korean J Gastroenterol.
- 2005 Oct;46(4):291-296.
BACKGROUND/AIMS: Hedgehog protein is an essential molecule for gastrointestinal tract development, and disruption of hedgehog signaling pathway is linked to some gastrointestinal tumorigenesis. Here, we performed hedgehog immunostaining in periampullary... -
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- Effect of Helicobacter pylori on Gastric Epithelial Cell Kinetics and Expression of Apoptosis-related Proteins in Gastric Carcinogenesis
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Lee KM, Lee DS, Yang JM, Ahn BM, Lee EH, Yoo JY, Kim YJ, Chung IS, Sun HS, Park DH
- KMID: 772516
- Korean J Gastroenterol.
- 2003 Jul;42(1):12-19.
BACKGROUND/AIMS: We investigated apoptosis, cell proliferation and the expression of apoptosis-related proteins in the gastric epithelial cells of Helicobacter pylori (H. pylori)-negative and positive patients. METHODS: TUNEL staining, immunohistochemical... -
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- Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of beta-catenin, leading to a rapid proliferation of pancreatic cells
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Cho IR, Koh SS, Min HJ, Kim SJ, Lee Y, Park EH, Ratakorn S, Jhun BH, Oh S, Johnston R, Chung YH
- KMID: 1097265
- Exp Mol Med.
- 2011 Feb;43(2):82-90.
- doi: 10.3858/emm.2011.43.2.010
It is not yet understood how the enhanced expression of pancreatic adenocarcinoma up-regulated factor (PAUF; a novel oncogene identified in our recent studies), contributes to the oncogenesis of pancreatic cells.... -
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- Detection of Epstein-Barr Virus by PCR and Expression of LMP1, p53, CD44 in Gastric Cancer
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Lee MA, Hong YS, Kang JH, Lee KS, You JY, Lee KY, Park CH
- KMID: 759684
- Korean J Intern Med.
- 2004 Mar;19(1):43-47.
BACKGROUND: Epstein-Barr virus (EBV) is associated with various lymphoproliferative disorders and nasopharyngeal carcinoma. Recently, some gastric cancer cells were observed to contain the EBV sequence. We detected EBV in gastric... -
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- P53 overexpression in gastric adenocarcinoma with Helicobacter pylori infection
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Chang KH, Kwon JW, Kim BS, Hwang JH, Lee SK, Lee YC, Park HJ, Park IS, Kim HK
- KMID: 699939
- Yonsei Med J.
- 1997 Apr;38(2):117-124.
- doi: 10.3349/ymj.1997.38.2.117
Gastric carcinogenesis has been studied in various aspects. Helicobacter pylori (Hp) infection and mutation of the p53 tumor suppressor gene have recently been argued to be important factors... -
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- Expression of Peroxisome Proliferato Activated Receptor gamma in Prostatic Adenocarcinoma
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Park HK, Kim H, Kim HG, Cho YM, Jung WY, Han HS, Hwang TS, Kwon GY, Lim SD
- KMID: 2155464
- J Korean Med Sci.
- 2015 May;30(5):533-541.
- doi: 10.3346/jkms.2015.30.5.533
Peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor has been investigated as the target for cancer treatment as well as metabolic disorders. Recent studies have demonstrated that PPAR-gamma ligands... -
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