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Inhibition of hepatitis B virus replication by RNA interference

Park YG

No abstract available.
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RNA Interference in Functional Genomics and Medicine

Kim VN

RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded RNA (dsRNA). Being a highly specific and efficient knockdown technique, RNAi not only provides a powerful tool for functional...
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RNA Interference in Infectious Tropical Diseases

Kang S, Hong YS

Introduction of double-stranded RNA (dsRNA) into some cells or organisms results in degradation of its homologous mRNA, a process called RNA interference (RNAi). The dsRNAs are processed into short interfering...
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Inhibition of in vitro hepatitis B virus replication by lentivirus-mediated short-hairpin RNA against HBx

Kim JW, Lee SH, Park YS, Jeong SH, Kim N, Lee DH

BACKGROUNDS/AIMS: Hepatitis B virus (HBV) replicates via RNA intermediates, which could serve as targets for RNA interference (RNAi). Vector-mediated short-hairpin RNA (shRNA) can induce sustained RNAi in comparison to small...
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Silencing IL-23 expression by a small hairpin RNA protects against asthma in mice

Li Y, Sun M, Cheng H, Li S, Liu L, Qiao H, Hua S, Lu J

To determine the impact of IL-23 knockdown by RNA interference on the development and severity of ovalbumin (OVA)-induced asthmatic inflammation, and the potential mechanisms in mice, the IL-23-specific RNAi-expressing pSRZsi-IL-23p19...
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Silencing of Long Non-Coding RNA MALAT1 Promotes Apoptosis of Glioma Cells

Xiang J, Guo S, Jiang S, Xu Y, Li J, Li L, Xiang J

The metastasis-associated lung adenocarcinoma transcription 1 (MALAT1) is a highly conserved long non-coding RNA (lncRNA) gene. However, little is known about the pathological role of lncRNA MALAT1 in glioma. In...
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Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma

Subramani , Lopez-Valdez R, Salcido A, Boopalan T, Arumugam A, Nandy S, Lakshmanaswamy R

Pancreatic cancer is the only major cancer with very low survival rates (1%). It is the fourth leading cause of cancer-related death. Hyperactivated growth hormone receptor (GHR) levels have been...
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The Effect of HIF-1alpha siRNA on Growth and Chemosensitivity of Mia-paca Cell Line

Yang L, Kang WK

PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) primarily mediates the hypoxic response. HIF-1alpha induction by various stimuli contributes to cell proliferation and survival. To investigate the effect of HIF-1alpha, we used small interfering...
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Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells

Hwang WC, Kim MK, Song JH, Choi KY, Min DS

Autophagy is a conserved lysosomal self-digestion process used for the breakdown of long-lived proteins and damaged organelles, and it is associated with a number of pathological processes, including cancer. Phospholipase...
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