- The Roles of Stromelysin-1 and the Gelatinase B Gene Polymorphism in Stable Angina
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Kim JS, Park HY, Kwon JH, Im EK, Choi D, Jang Y, Cho SY
- KMID: 1122006
- Yonsei Med J.
- 2002 Aug;43(4):473-481.
- doi: 10.3349/ymj.2002.43.4.473
Matrix metalloproteinases contribute to vascular remodeling by breaking down extracellular-matrix while new matrix is synthesized. Of the variety of MMPs, stromelysin-1 and gelatinase B may have key roles in coronary... -
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- Lack of Relationship between Vitamin D Receptor Polymorphism and Bone Erosion in Rheumatoid Arthritis
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Lee CK, Hong JS, Cho YS, Yoo B, Kim GS, Moon HB
- KMID: 648255
- J Korean Med Sci.
- 2001 Apr;16(2):188-192.
- doi: 10.3346/jkms.2001.16.2.188
We performed this study to investigate the possible association between vitamin D receptor (VDR) gene polymorphism and the focal bone erosion in rheumatoid arthritis (RA) patients in Korea. One hundred... -
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- Angiotensin converting enzyme gene polym orphism in Korean patients with primary knee osteoarthritis
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Hong SJ, Yang HI, Yoo MC, In CS, Yim SV, Jin SY, Choe BK, Chung JH
- KMID: 1094700
- Exp Mol Med.
- 2003 Jun;35(3):189-195.
Angiotensin converting enzyme (ACE) plays an important role in the physiology of vasculature, blood pressure and inflammation. ACE gene, known to have insertion/deletion (I/D) polymorphism, has been widely investigated in... -
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- Analysis of polymorphic region of GAM-1 gene in Plasmodium vivax Korean isolates
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Kho WG, Chung JY, Hwang UW, Chun JH, Park YH, Chung WC
- KMID: 1720402
- Korean J Parasitol.
- 2001 Dec;39(4):313-318.
- doi: 10.3347/kjp.2001.39.4.313
The identification, characterization and quantification of Plasmodium sp. genetic polymorphism are becoming increasingly important in the vaccine development. We investigated polymorphism of Plasmodium vivax GAM-1 (PvGAM-1) gene in 30 Korean... -
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- Tumor Necrosis Factor-alpha Levels and Promoter Polymorphism in Patients with Kawasaki Disease in Korea
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Ahn SY, Jang GC, Shin JS, Shin KM, Kim DS
- KMID: 1091043
- Yonsei Med J.
- 2003 Dec;44(6):1021-1026.
- doi: 10.3349/ymj.2003.44.6.1021
Tumor necrosis factor (TNF) -alpha plays a major role in the pathogenesis of Kawasaki disease (KD), a systemic vasculitis primarily affecting young children. We performed this study to examine the... -
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- Association of Angiotensin-Converting Enzyme and Angiotensinogen Gene Polymorphisms with Preeclampsia
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Choi H, Kang JY, Yoon HS, Han SS, Whang CS, Moon IG, Shin HH, Park JB
- KMID: 1733485
- J Korean Med Sci.
- 2004 Apr;19(2):253-257.
- doi: 10.3346/jkms.2004.19.2.253
We tested the hypothesis that angiotensin-converting enzyme (ACE) and angiotensinogen gene polymorphism influence the incidence, development and outcome of preeclampsia. Subjects were recruited from 90 Korean patients with preeclampsia during... -
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- Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients
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Seo JC, Han SW, Yin CS, Koh HK, Kim CH, Kim EH, Leem KH, Lee HS, Park HJ, Kim SA, Choe BK, Lee HJ, Yim SV, Kim CJ, Chung JH
- KMID: 931880
- Exp Mol Med.
- 2002 Sep;34(4):294-298.
Apoptosis has been implicated in the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. Apo-1/Fas gene is one of the mediators of apoptosis in stroke. MvaI polymorphism... -
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- Relation of Apolipoprotein E Polymorphism to Clinically Diagnosed Fatty Liver Disease
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Lee DM, Lee SO, Mun BS, Ahn HS, Park HY, Lee HS, Kim DG
- KMID: 863110
- Korean J Hepatol.
- 2002 Dec;8(4):355-362.
BACKGROUND/AIMS: Apolipoprotein E (Apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major Apo E isoforms are encoded by three... -
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- Effects of Val34Leu and Val35Leu polymorphism on the enzyme activity of the coagulation factor XIII-A
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Lee IH, Chung SI, Lee SY
- KMID: 755212
- Exp Mol Med.
- 2002 Nov;34(5):385-390.
Change in fibrin stabilizing activity of factor XIII A subunit (FXIII-A) caused by a specific mutation, Val34Leu, is recently implicated to incidences of pathophysiology of thrombosis. In an effort to... -
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- Association between Bone Mineral Density and LDL Receptor-Related Protein 5 Gene Polymorphisms in Young Korean Men
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Koh JM, Jung MH, Hong JS, Park HJ, Chang JS, Shin HD, Kim SY, Kim GS
- KMID: 1786820
- J Korean Med Sci.
- 2004 Jun;19(3):407-412.
- doi: 10.3346/jkms.2004.19.3.407
Recently, It has been reported that the LDL receptor-related protein 5 (LRP5) regulates bone formation, and that mutations of the gene cause osteoporosis-pseudoglioma syndrome or high bone mass phenotypes. However,... -
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- Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates
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Kho WG, Chung JY, Sim EJ, Kim DW, Chung WC
- KMID: 1039036
- Korean J Parasitol.
- 2001 Jun;39(2):143-150.
- doi: 10.3347/kjp.2001.39.2.143
The present study was designed to investigate polymorphism in Duffy binding protein (DBP) gene of Plasmodium vivax isolates of Korea. Thirty samples were obtained from P. vivax patients in Yonchon-gun,... -
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- Apolipoprotein E Gene Polymorphism and Serum Lipids in Patients with Superficial Fungal Disease
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Tursen U, Kaya TI, Eskandari , Bocekli E, Muslu N, Camdeviren H, Ikizoglu G, Atik U
- KMID: 1734117
- Yonsei Med J.
- 2004 Jun;45(3):375-379.
- doi: 10.3349/ymj.2004.45.3.375
Superficial mycosis, including dermatophytic infections, tinea versicolor, and cutaneous candidiasis is mostly limited to the outer layers of the skin, nails, and mucous membranes. In this study, Apolipoprotein E (ApoE)... -
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- Interstrain polymorphisms of isoenzyme profiles and mitochondrial DNA fingerprints among seven strains assigned to Acanthamoeba polyphaga
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Kong HH, Park JH, Chung DI
- KMID: 1715376
- Korean J Parasitol.
- 1995 Dec;33(4):331-340.
- doi: 10.3347/kjp.1995.33.4.331
Interstrain polymorphisms of isoenzyme profiles and mitochondrial (Mt) DNA fingerprints were observed among seven strains of Acanthamoeba isolated from different sources and morphologically assigned to A. polyphaga. Mt DNA fingerprints... -
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- Association of the Gene Polymorphisms of Platelet Glycoprotein Ia and IIb/IIIa with Myocardial Infarction and Extent of Coronary Artery Disease in the Korean Population
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Park S, Park HY, Park C, Ko YG, Im EK, Jo I, Shin C, Lee JB, Shim WH, Cho SY, Jang Y
- KMID: 1734124
- Yonsei Med J.
- 2004 Jun;45(3):428-434.
- doi: 10.3349/ymj.2004.45.3.428
Platelet membrane receptor glycoproteins (GP) are essential for the platelet activation process, and the genetic polymorphisms in the genes that encode platelet glycoproteins have been proposed to influence the risk... -
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- Association Between Polymorphisms of Ethanol-Metabolizing Enzymes and Susceptibility to Alcoholic Cirrhosis in a Korean Male Population
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Lee HC, Lee HS, Jung SH, Yi SY, Jung HK, Yoon JH, Kim CY
- KMID: 648356
- J Korean Med Sci.
- 2001 Dec;16(6):745-750.
- doi: 10.3346/jkms.2001.16.6.745
Alcohol is oxidized to acetaldehyde by alcohol dehydrogenase (ADH) and cytochrome P-4502E1 (CYP2E1), and then to acetate by aldehyde dehydrogenase (ALDH). Polymorphisms of these ethanol-metabolizing enzymes may be associated with... -
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- A Study of Polymorphism in UDP-glucuronosyltransferase 1 (UGT-1A1) Promoter Gene in Korean Patients with Gilbert's Syndrome
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Kim YH, Yeon JE, Jung GM, Kim HJ, Kim JS, Byun KS, Bak YT, Lee CH
- KMID: 1123162
- Korean J Hepatol.
- 2002 Jun;8(2):132-138.
BACKGROUNDS/AIMS: Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to about 30 percent of normal in patients with Gilbert's syndrome. Patients with Gilbert's syndrome have an... -
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- Renin-Angiotensin-Aldosterone System (RAAS) Gene Polymorphism as a Risk Factor of Coronary In-Stent Restenosis
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Ryu SK, Cho EY, Park HY, Im EK, Jang Y, Shin GJ, Shim WH, Cho SY
- KMID: 1122005
- Yonsei Med J.
- 2002 Aug;43(4):461-472.
- doi: 10.3349/ymj.2002.43.4.461
Intimal proliferation is a main cause of in-stent restenosis. Over-excretion of angiotensin I converting enzyme (ACE) and aldosterone is reported to stimulate intimal hyperplasia and the genetic effect of these... -
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