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Transgenesis for pig models

Yum SY, Yoon KY, Lee CI, Lee BC, Jang G

Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT)....
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Development of a Rat Model of Graded Contusive Spinal Cord Injury Using a Pneumatic Impact Device

Yeo SJ, Hwang SN, Park SW, Kim YB, Min BK, Kwon JT, Suk JS

An animal model of spinal cord trauma is essential for understanding the injury mechanisms, cord regeneration, and to aid the development of new therapeutic modalities. This study focused on the...
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The Fetal Sheep: A Unique Model System for Assessing the Full Differentiative Potential of Human Stem Cells

Porada GA, Porada C, Zanjani ED

The naturally occurring stem cell migratory patterns, the availability of expanding homing and engraftment sites, and the presence of tissue/organ-specific signals in the developing mammalian fetus provide the ideal setting...
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Snapshot of degenerative aging of porcine intervertebral disc: a model to unravel the molecular mechanisms

Cho H, Park SH, Lee S, Kang M, Hasty KA, Kim SJ

Larger animal models, such as porcine, have been validated as appropriate models of the human disc with respect to biomechanics and biochemistry. They are advantageous for research as the models...
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Does the Tibial and Sural Nerve Transection Model Represent Sympathetically Independent Pain?

Han DW, Kweon TD, Kim KJ, Lee JS, Chang CH, Lee YW

Neuropathic pain can be divided into sympathetically maintained pain (SMP) and sympathetically independent pain (SIP). Rats with tibial and sural nerve transection (TST) produce neuropathic pain behaviors, including spontaneous pain,...
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Comparison of cardiac function and coronary angiography between conventional pigs and micropigs as measured by multidetector row computed tomography

Ahn YK, Ryu JM, Jeong HC, Kim YH, Jeong MH, Lee MY, Lee SH, Park JH, Yun SP, Han HJ

Pigs are the most likely source animals for cardiac xenotransplantation. However, an appropriate method for estimating the cardiac function of micropigs had not been established. Computed tomography (CT) analysis aimed...
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