- Comparison of two dosing regimens of aminoglycosides for the development of nephrotoxicity: once versus multiple daily dosing
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Choi BD, Kim BN
- KMID: 2305955
- Korean J Med.
- 2006 Nov;71(5):543-550.
BACKGROUND: Aminoglycosides are useful for the treatment of aerobic gram-negative infections, and this is despite the narrow therapeutic index and the potential nephrotoxicity and ototoxicity. Once daily dosing of aminoglycosides... -
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- Once daily dosing of aminoglycoside in children
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Shin SH
- KMID: 2280308
- Korean J Pediatr.
- 2008 Oct;51(10):1038-1041.
- doi: 10.3345/kjp.2008.51.10.1038
Aminoglycosides are frequently used antibiotics in children. The multiple daily dosing (MDD) in infants and children is twice or three times daily depending on age. Recent studies in adults have... -
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- Aminoglycoside Resistance in Gram-negative Bacilli
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Park YJ
- KMID: 1469953
- Korean J Clin Microbiol.
- 2009 Jun;12(2):57-61.
- doi: 10.5145/KJCM.2009.12.2.57
Aminoglycosides are one of the clinically relevant antibiotics. They kill bacteria by binding to bacterial 30S subunit of ribosome. Resistance to aminoglycosides occurs by three different mechanisms: 1. Production of... -
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- Antimicrobial resistance in enterococci
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Pai CH, Kim MN
- KMID: 711598
- Yonsei Med J.
- 1998 Dec;39(6):554-561.
- doi: 10.3349/ymj.1998.39.6.554
Enterococci have emerged as a major nosocomial pathogen and as an ever-increasing problem in antimicrobial resistance. They are ubiquitous in the intestinal flora of humans and animals and inherently resistant... -
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- Therapeutic Drug Monitoring (TDM) of Antimicrobial Agents
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Kim SW
- KMID: 1782285
- Infect Chemother.
- 2008 Jun;40(3):133-139.
- doi: 10.3947/ic.2008.40.3.133
Optimal exposure of certain antimicrobials and minimization of their toxicity can be achieved by therapeutic drug monitoring (TDM) of antimicrobial agents. Vancomycin and aminoglycosides are most frequently monitored because of... -
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- Antimicrobial-induced Electrolyte and Acid-Base Disturbances
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Kim YW
- KMID: 2052293
- Electrolyte Blood Press.
- 2007 Dec;5(2):111-115.
- doi: 10.5049/EBP.2007.5.2.111
Antimicrobials are one of the most widely prescribed classes of therapeutic agents. Although adverse effects of antimicrobials are generally minimal and reversible, serious sequelae can sometimes remain, such as unusual... -
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- Effect of Intrav it real Ceftazidime Injection in Experimental Pseudomonas Endophthalmitis
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Lee WJ, Lee JH, Kim JS
- KMID: 2205593
- J Korean Ophthalmol Soc.
- 1999 Oct;40(10):2708-2716.
Aminoglycosides have been used in Gram negative bacterial endoph-thalmitis as mainstay of treatment but may have potential retinal toxicity when injected intravitreally. This investigation was conducted to evaluate the efficacy... -
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- Update of Research on Aminoglycoside Ototoxicity
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Byun JY
- KMID: 2277304
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2012 Jan;55(1):1-7.
- doi: 10.3342/kjorl-hns.2012.55.1.1
It has long been known that the major irreversible toxicity of aminoglycosides is ototoxicity. Among them, streptomycin and gentamicin are primarily vestibulotoxic, whereas amikacin, neomycin, dihydrosterptomycin, and kanamicin are primarily... -
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- Bilateral Vestibulopathy
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Kim M, Kim KS
- KMID: 2277871
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2013 Mar;56(3):131-137.
- doi: 10.3342/kjorl-hns.2013.56.3.131
Bilateral vestibulopathy (BV) is a clinical entity with impaired function of bilateral peripheral vestibular system, which is characterized by movement-induced postural vertigo, oscillopsia and unsteadiness of gait. The possible causes... -
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- Effect of Aminoglycosides on Leukochemotaxis in Rats
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Kim KC, Kim SH
- KMID: 1668183
- J Korean Pediatr Soc.
- 1980 Nov;23(11):889-900.
In order to study the effects of aminoglycosides on leukochemotaxis in rats, the degree of leukocyte infiltration and differential leukocyte count were observed at the experimentally inflamed tissue by incision... -
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- The Effect of Aminoglycoside Restriction on the Resistance Pattern and Mortality of Nosocomial Bacteremia Caused by Gram-Negative Bacilli
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Oh JT, Kim SW, Son JW, Do BH, Han SW, Shin BC, Park JH, Lee JM, Kim NS
- KMID: 1515438
- Infect Chemother.
- 2003 Aug;35(4):192-198.
OBJECTIVE:To evaluate the effects of an aminoglycoside restriction policy on expenditures for aminoglycosides, antimicrobial resistance rates and clinical outcome of nosocomial bacteremia caused by Gram-negative bacilli (GNB). METHODS: Starting in... -
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- Antimicrobial Therapy for Infections Caused by Carbapenem-Resistant Gram-Negative Bacteria
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Wi YM, Kang CI
- KMID: 2446985
- Korean J Med.
- 2018 Oct;93(5):439-446.
- doi: 10.3904/kjm.2018.93.5.439
Carbapenem-resistance emerging in Gram-negative pathogens, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, has become a major human health problem globally. The therapeutic options available for carbapenem-resistant pathogens are... -
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- Intratympanic Drug Injection for Inner Ear Disease
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Yang HC, Cho HH
- KMID: 2277805
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2014 Jun;57(6):364-372.
- doi: 10.3342/kjorl-hns.2014.57.6.364
During treatment of inner ear diseases, the blood-cochlear barrier limits the drug delivery into the cochlea. Intratympanic drug injection for inner ear diseases is a safe procedure where drugs reach... -
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- Asymmetric Audiovestibular Dysfunction in Patients With Systemic Aminoglycoside Treatment
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Park JH, Rah YC, Kim JS, Koo JW
- KMID: 1426866
- Res Vestib Sci.
- 2013 Jun;12(2):62-66.
Since the characteristics of aminoglycoside ototoxicity is typically bilaterally symmetric progression of cochlea-vestibular dysfunction, a unilateral involvement has rarely been reported. However, ototoxicity can be asymmetric or focal after systemic... -
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- Evaluating Home-made Disks for the Detection of the Aminoglycoside High-Level Resistance of Enterococci
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Kim SR, Jeong J, Shin JH, Kim HH, Lee SH, Chang CL, Son HC
- KMID: 2089636
- Korean J Clin Pathol.
- 2000 Aug;20(4):379-383.
BACKGROUND: High-level gentamicin and streptomycin disks are not easily available, despite their critical role in detection of high-level resistance to aminoglycosides in enterococci. Therefore, the possibility of applicating home-made disks... -
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- 4 Cases of Pseudomembranous Colitis Confirmed by Clostridium Culture
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Lee NM, Won JH, Lee MS, Kim JH, Cho SW, Shim CS
- KMID: 1928914
- Korean J Gastrointest Endosc.
- 1989 Nov;9(2):221-226.
Diarrhea is a common complication of antibiotics usage. The diarrhea ascribed to antibiotics usually consist of loose or watery stools, sometimes containing mucus but rarely grossly evident blood. Almost every... -
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- Antibiotic Therapy for Pediatric Patients
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Kim KH
- KMID: 2347586
- J Korean Med Assoc.
- 2002 Jun;45(6):780-792.
- doi: 10.5124/jkma.2002.45.6.780
Antibiotics are prescribed to prevent infection and to treat established or presumptive infections. In choosing the appropriate antibiotics, a number of factors must be considered. First, the identity of the... -
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- Extensively Drug Resistant-Tuberculosis, XDR-TB
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Park JS
- KMID: 2185734
- J Korean Med Assoc.
- 2008 Feb;51(2):168-175.
- doi: 10.5124/jkma.2008.51.2.168
Multidrug-resistant tuberculosis(MDR-TB), resistant to at least the two main TB drugsisoniazid and rifampicin, has been a threat to TB control because the treatment requires more toxic drugs and longer period... -
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- Pharmacokinetics of Gentamicin and Amikacin in Korean Children with Normal Renal Function
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Park JY, Kwon KB, Kim MR, Lee HJ, Kim JQ, Shin WG, Park KH, Chung HL
- KMID: 2335085
- J Korean Pediatr Soc.
- 1994 Feb;37(2):185-192.
We analysed retrospectively pharmacokinetic parameters of gentamicin and amikacin in 44 and 58 Korean pediatric patients, respectively, with normal renal function. Pharmacokinetic parameters were calculated from two concentrations in serum... -
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- Therapeutic Effect of Rifampin in Shigellosis
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Lee C, Sul JH, Kim PK, Yun DJ
- KMID: 2142500
- J Korean Pediatr Soc.
- 1980 Oct;23(10):791-797.
Twenty one infants and children were entered into the study protocol when bacteriologic diagnosis of shigellosis was made by stool culture indenification. Fifteen patients were treated at Inje Hospital in... -
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