J Korean Med Sci.  2000 Oct;15(5):598-600. 10.3346/jkms.2000.15.5.598.

Technetium-99m MDP bone scintigraphic findings of hypercalcemia in accelerated phase of chronic myelogenous leukemia

• Kwak HS
• Sohn MH
• Lim ST
• Kwak JY
• Yim CY

• KMID: 965886
• DOI: http://doi.org/10.3346/jkms.2000.15.5.598

Abstract

Hypercalcemia in accelerated phase of chronic myelogenous leukemia (CML) is very rare. Its pathogenesis is considered humoral hypercalcemia of malignancies mediated by parathyroid hormone-related protein (PTHrP). In severe hypercalcemia, calcifications in kidneys, skin, vessels, heart, and stomach may occur. Our two cases were admitted because of severe hypercalcemia in accelerated phase of CML. On Tc-99m methylene diphosphonate (MDP) bone scintigraphies, a marked tracer accumulation was seen in the lung, heart, stomach and kidney. We report increased tracer accumulation of multiple organs on Tc-99m MDP bone scintigraphy in two rare hypercalcemic patients with CML.

Keyword

Leukemia, Myeloid, Chronic; Hypercalcemia; Radionuclide Imagin

MeSH Terms

Adult
Bone Diseases/radionuclide imaging*
Bone Diseases/etiology*
Calcinosis/radionuclide imaging
Calcinosis/etiology
Case Report
Human
Hypercalcemia/radionuclide imaging*
Hypercalcemia/etiology*
Leukemia, Myeloid, Chronic/metabolism
Leukemia, Myeloid, Chronic/complications*
Male
Middle Age
Proteins/metabolism
Technetium/diagnostic use