J Korean Med Sci.  2000 Oct;15(5):545-550. 10.3346/jkms.2000.15.5.545.

Sebaceous carcinoma of the eyelids: frequent expression of c-erbB-2 oncoprotein

• Cho KJ
• Khang SK
• Koh JS
• Chung JH
• Lee SS

• KMID: 965877
• DOI: http://doi.org/10.3346/jkms.2000.15.5.545

Abstract

Ocular sebaceous carcinoma (OSC) is an uncommon malignancy with a potential to recur and metastasize. Some characteristics of sebaceous carcinoma, such as female preponderance, shown in the present series during 11-year period at Korea Cancer Center Hospital, led us to study their hormone receptors and c-erbB-2 expression. c-erbB-2 overexpression was very common (83%) in OSC, and was not associated with pathologic findings or clinical outcome. Interestingly, estrogen and progesterone receptor was detected in 4 and 2 cases, respectively, suggesting a role of hormonal influence on this neoplasm. Immunohistochemical and clinicopathologic features of 18 cases of OSC in Korea are presented.

Keyword

Carcinoma; Sebaceous Glands; Eyelids; Immunohistochemistry; erbB-2; Receptors, Estrogen; Receptors, Progesterone

MeSH Terms

Adult
Aged
Aged, 80 and over
Carcinoma/pathology*
Carcinoma/metabolism
Carcinoma/chemistry
Eyelid Neoplasms/pathology*
Eyelid Neoplasms/metabolism
Eyelid Neoplasms/chemistry
Female
Human
Immunohistochemistry
Male
Middle Age
Necrosis
Receptor, erbB-2/biosynthesis*
Receptor, erbB-2/analysis
Receptors, Estrogen/analysis
Receptors, Progesterone/analysis
Sebaceous Gland Neoplasms/pathology*
Sebaceous Gland Neoplasms/metabolism
Sebaceous Gland Neoplasms/chemistry