Exp Mol Med.
2010 Jan;42(1):12-20. 10.3858/emm.2010.42.1.007.
Further understanding of fat biology: Lessons from a fat fly
- Affiliations
-
- 1Graduate School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea.
- 2Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon 440-746, Korea. kwpark@skku.edu
- KMID: 946665
- DOI: http://doi.org/10.3858/emm.2010.42.1.007
Abstract
- Obesity is a leading risk factor for insulin resistance, hypertension, hyperlipidemia, and cardiovascular complications, collectively referred to as metabolic diseases. Given the prevalence of obesity and its associated medical problems, new strategies are required to prevent or treat obesity and obesity-related metabolic effects. Here we summarize contributors of obesity, and molecular mechanisms controlling adipogenesis from studies in mammalian systems. We also discuss the possibilities of using Drosophila as a genetic model system to advance our understanding of players in fat biology.
