J Korean Med Sci.  1995 Dec;10(6):406-413. 10.3346/jkms.1995.10.6.406.

Expression of p53 and NDP-K/nm23 in gastric carcinomas: association with metastasis and clinicopathologic parameters

• Kim KM
• Lee A
• Chae HS
• Shim SI

• KMID: 927171
• DOI: http://doi.org/10.3346/jkms.1995.10.6.406

Abstract

To evaluate the role of p53 and NDP-K/nm23(nm23) protein as a prognostic factor and their relation to metastasis of cancer, we studied metastatic and nonmetastatic gastric carcinoma specimens by immunohistochemical staining. Among the 101 specimens examined, 37(36.6%) showed positivity in staining for p53 protein and 64(63.4%) showed no detectable p53 protein in tumor cells. p53 overexpression was correlated with depth of invasion, lymphatic invasion, lymph node metastasis and distant metastasis. Out of 101 specimens, 35 cases had no staining for nm23. 62 cases(61.4%) exhibited a cytoplasmic staining on most cells and 42 cases (41.6%) had nuclear staining. In 16 of 101 cases(15.8%), a mild to moderate membranous staining was observed in some cells. Cytoplasmic nm23 expression was negatively correlated with lymph node metastasis(P < 0.01) and distant metastasis(P < 0.01). The nuclear nm23 expression showed negative correlation with depth of invasion(P < 0.01), lymphatic invasion(P < 0.01), lymph node metastasis(P < 0.01), and distant metastasis(P < 0.04). The membranous nm23 expression revealed negative correlation with lymphatic invasion(P < 0.02), lymph node metastasis(P < 0.01) and distant metastasis(P < 0.02).

Keyword

p53; nm23; Gastric carcinoma; Metastasis; Prognosis

MeSH Terms

Adult
Aged
Aged, 80 and over
Female
*Gene Expression Regulation, Neoplastic
Human
Immunohistochemistry
Male
Middle Age
Neoplasm Metastasis
Nucleoside-Diphosphate Kinase/*analysis
Prognosis
Protein p53/*genetics
Stomach Neoplasms/*chemistry/*pathology
Support, Non-U.S. Gov't
Transcription Factors/*genetics