J Korean Acad Nurs.  2006 Dec;36(7):1204-1214.

Status of Nosocomial Urinary Tract Infections in the ICU: Molecular Epidemiology of Imipenem Resistant P. aeruginosa

• Yu SM
• Jeon SS
• Kang IS
• An HG

Abstract

PURPOSE: This retrospective study was done to evaluate the status of nosocomial urinary tract infections and to determine the risk factors andtransmission route of causal IRPA through molecular epidemiology. METHOD: Two hundred ninety-nine of 423 patients admitted to the internal medicine and surgery ICU at a university hospital incity B had a positiveurine culture. Twelve of the 299 patients who had a urinary tract infection had IRPA strains. The data was collected from November 1, 2004 to January 31, 2005. The following results were obtained after the data was analyzed using percentile and UPGMA. RESULT: The rate of nosocomial urinary tract infections in the ICU was 10.8%. Therewere 16.8 cases of infection based on the period of hospitalization. There were 16.9 cases of infection based on the use of a foley catheter. The rate of nosocomial urinary tract infection in the ICU and urinary tract infections related to IRPA were higher in patients with the following characteristics: men, old age, admission through the emergency room, longer than seven days admission, severity of admitting causes, disturbance of consciousness, hydration less than 300cc in 24hours, a long course of antibiotics, a long period of foley catheterization and perineal care. Most of the microorganisms that caused the urinary tract infection were gram negative bacilli, among which P. aeruginosa was found in 70 patients (18.5%) and IRPA in 12 (4.0%). Among the 12 IRPA strains that were tested with PFGE, eight showed a dice coefficient higher than 80%, suggesting a genetic relationship. They were related with the period of hospitalization in the same ICU. These patients all received direct care for a urinary tract infection. CONCLUSION: Through these results, IRPA can be consideredas a contributing factors to urinary tract infections thus, active preventative measures are needed by the medical staff.

Keyword

Nosocomial urinary tract infection; Molecular epidemiology; Imipenem resistant P. aeruginosa

MeSH Terms

Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents/*pharmacology
Cross Infection/*epidemiology/etiology/microbiology
Drug Resistance, Bacterial
Female
Humans
Imipenem/*pharmacology
Intensive Care Units
Male
Middle Aged
Pseudomonas Infections/drug therapy/*epidemiology
Pseudomonas aeruginosa/classification/drug effects/*genetics
Retrospective Studies
Risk Factors
Urinary Catheterization
Urinary Tract Infections/*epidemiology/etiology/microbiology