Korean J Gastroenterol.  2008 Feb;51(2):101-110.

Radiation Therapy in Pancreatic Cancer

• Chie EK

Abstract

Radiotherapy has been offered to patients with pancreatic cancer, either in the adjuvant or definitive setting. However, the role of radiotherapy in pancreatic cancer is increasingly doubted, especially after the introduction of gemcitabine to both domains. Although contradictory data exist, combined chemoradiotherapy improves both quantity and quality of life for patients with locally advanced tumors compared with radiotherapy alone or chemotherapy alone. Recently, induction chemotherapy strategy is being evaluated for better selection of patients for optimal benefit from consolidative chemoradiotherapy. Much controversy has been suggested concerning the role of adjuvant radiotherapy, but quality assurance for radiotherapy was not considered in the previously reported studies. Combined chemoradiotherapy in the adjuvant setting is still considered as a viable option. Current phase III randomized on-going studies will provide better answers on the role of radiotherapy in the treatment of pancreatic cancer.

Keyword

Pancreatic cancer; Chemoradiotherapy

MeSH Terms

Antimetabolites/therapeutic use
Antimetabolites, Antineoplastic/therapeutic use
Combined Modality Therapy
Deoxycytidine/analogs & derivatives/therapeutic use
Fluorouracil/therapeutic use
Humans
Pancreatic Neoplasms/drug therapy/*radiotherapy