Korean J Gastroenterol.  2006 Feb;47(2):131-135.

Comparison of the Effectiveness of Quadruple Salvage Regimen for Helicobacter pylori Infection according to the Duration of Treatment

• Choung RS
• Lee SW
• Jung SW
• Han WS
• Kim MJ
• Jeen YT
• Park JJ
• Lee HS
• Chun HJ
• Um SH
• Choi JH
• Kim CD
• Ryu HS
• Hyun JH

Abstract

BACKGROUND/AIMS: At present, triple therapy schemes are recommended by national and international consensus conferences for the treatment of Helicobacter pylori (H. pylori) infection. However, even with the most effective current treatment regimens, about 10-20% of patients fail to eradicate H. pylori, necessitating alternative strategy to eradicate H. pylori in primary treatment failure. Therefore, we performed this study to evaluate the efficacy of quadruple therapy and to compare 1 and 2-week quadruple regimen as a second-line therapy. METHODS: The hospital records of 155 patients who failed to the standard triple therapy (proton pump inhibitor, amoxicillin, clarithromycin) were reviewed retrospectively, and divided the 1 or 2 weeks OBMT regimen (omeprazole 20 mg bid, bismuth salt 120 mg qid, metronidazole 500 mg tid, tetracycline 500 mg qid). Presence of H. pylori infection and side-effects of the treatment regimen were assessed 4 weeks after the cessation of treatment. CONCLUSIONS: One hundred and eight male and 47 female (mean age, 52.2+/-15.4) patients were enrolled. The overall eradication rate of H. pylori with quadruple therapy was 83.9% and the eradication rate was similar between 1 and 2 weeks of OBMT regimen (76.8% in OBMT 1 week, 87.9% in OBMT 2 weeks, respectively p=0.110). CONCLUSIONS: Quadruple therapy is an effective salvage regimen for H. pylori eradication after the failure of standard triple therapy. One week quadruple therapy is not significantly different from 2-weeks regimen as the second-line option for H. pylori eradication.

Keyword

Helicobacter pylori; Second-line quadruple therapy; Duration of treatment

MeSH Terms

Adult
Aged
Anti-Bacterial Agents/administration & dosage
Anti-Ulcer Agents/administration & dosage
Drug Administration Schedule
Drug Therapy, Combination
Female
Helicobacter Infections/*drug therapy
*Helicobacter pylori
Humans
Male
Middle Aged
Proton Pumps/antagonists & inhibitors