Korean J Hepatol.  2007 Sep;13(3):341-348. 10.3350/kjhep.2007.13.3.341.

Short-term Therapy with Pegylated Interferon plus Ribavirin for the Chronic Hepatitis C Genotype 2 Patients

• Jung EU
• Park JH
• Pae KI
• Kang SW
• Park SJ
• Jee SR
• Park ET
• Lee YJ
• Lee SH
• Seol SY

• KMID: 760735
• DOI: http://doi.org/10.3350/kjhep.2007.13.3.341

Abstract

BACKGROUND/AIMS: The standard treatment for chronic hepatitis C patients infected with HCV genotype-2 is a combination of pegylated interferon alfa and ribavirin over a 24 week period. It is unclear if a shorter treatment duration is possible for patients showing a rapid virological response (RVR) without compromising the sustained virologic response (SVR) in Korea. METHODS: 42 patients chronically infected with the HCV genotype-2 were treated with peginterferon alfa-2a 180 mcg/wk plus ribavirin 800 mg/d for 24 weeks and followed up for 24 weeks. The HCV RNA was qualitatively assessed after 4 weeks of treatment, and RVR was defined as undetectable HCV RNA at the 4th week. Retrospectively, 26 patients were treated with the standard treatment strategy (> or =80% of the intended duration and dosage), 14 patients with a short-term treatment strategy (<80% intended duration and dosage) and 2 patients were excluded. RESULTS: Among the 42 patients, 35 patients (83%) had RVR and 38 patients (90%) had a sustained virologic response (SVR). All 7 patients without RVR were treated with the standard treatment strategy, in whom 6 patients (86%) had SVR. Among the 35 patients with RVR, 14 patients were treated with short-term treatment and 19 patients were treated with the standard treatment. SVR was obtained in 12 out of the 14 patients (86%) in the short-term treatment group and 18 out of the 19 (95%) in the standard treatment group (P=0.373). CONCLUSION: HCV genotype-2 patients who have RVR with peginterferon and ribavirin treatment can be treated with a short-term treatment without compromising the chances for SVR. However, an additional trial will be needed to optimize the treatment duration.

Keyword

Hepatitis C; Peginterferon; Ribavirin; Rapid virologic response; Short-term treatment

MeSH Terms

Adolescent
Adult
Aged
Antiviral Agents/*administration & dosage/therapeutic use
Data Interpretation, Statistical
Drug Therapy, Combination
Female
Genotype
Hepacivirus/genetics
Hepatitis C, Chronic/*drug therapy
Humans
Interferon Alfa-2a/*administration & dosage/therapeutic use
Male
Middle Aged
Polyethylene Glycols/*administration & dosage/therapeutic use
Retrospective Studies
Ribavirin/*administration & dosage/therapeutic use
Time Factors
Treatment Outcome