Korean J Intern Med.
2003 Sep;18(3):202-205.
A Case of Non-Hodgkin's Lymphoma in a patient with Neurofibromatosis Type 1
- Affiliations
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- 1Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. cancer@korea.ac.kr
- 2Department of Pathology, Korea University College of Medicine, Seoul, Korea.
- 3Department of Diagnostic Radiology, Korea University College of Medicine, Seoul, Korea.
- 4Department of Diagnostic Radiology, Konkuk University College of Medicine, Chungju, Korea.
Abstract
- Neurofibromatosis type 1 is characterized by cutaneous neurofibromas and pigmented lesions of the skin called cafe au lait spots. Although neurofibromatosis type 1 represents a major risk factor for the development of malignancy, especially of nervous system tumors, malignant lymphoma rarely occurs in a patients with neurofibromatosis type 1. Recently, a 77-year-old woman with neurofibromatosis type 1 was diagnosed as non-Hodgkin's Lymphoma (diffuse large B cell). She had multiple cafe au lait spots, neurofibromas and right axillary lymph node enlargement. An abdominal CT scan demonstrated a left pelvic mass and para-aortic lymphadenopathy. Because non-Hodgkin's Lymphoma in a neurofibromatosis patient has never been reported in Korea, herein, we describe this case and include a review of the literature.
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