Korean J Intern Med.  2002 Sep;17(3):191-197.

Primary Lymphoma of Bone: Survival and Prognosis

• Choi JY
• Hahn JS
• Suh CO
• Yang WI

Abstract

BACKGROUND: Primary lymphoma of bone is a rare disease. There is yet no systematical evaluation of primary lymphoma of bone in Korea. Here we report our experience of sixteen cases with primary lymphoma of bone focusing on the survival. METHODS: Sixteen cases, collected for 13 years, were evaluated on the clinical presentation, histologic subtype, stage and treatment outcomes of the primary bone lymphoma. RESULTS: The most common presenting complaint was bone pain. Malignant lymphoma of bone involved a wide variety of sites, the most prevalent site of which in this study was the spine. Most of the cases were in the diffuse large B-cell category. The clinical stage of lymphoma was IEA in two cases, IIEA in three cases, IVEA in five cases and IVEB in three cases. All treated cases received systemic chemotherapy and ten cases among them were treated with combined modality therapy. Median overall survival was not reached after median follow-up period of 28 months and five-year overall survival rate was 54%. CONCLUSION: More promising therapeutic strategies are needed for survival improvement on more accumulated cases.

Keyword

Bone and Bones; Lymphoma; Survival; Prognosis

MeSH Terms

Adolescent
Adult
Aged
Bone Neoplasms/*mortality/pathology/therapy
Child
Child, Preschool
Female
Human
Infant
Korea/epidemiology
Lymphoma/*mortality/pathology/therapy
Male
Middle Age
Neoplasm Staging
Prognosis
Retrospective Studies
Survival Rate