Korean J Ophthalmol.  2003 Jun;17(1):35-43. 10.3341/kjo.2003.17.1.35.

Clinical Result of Prolonged Primary Chemotherapy in Retinoblastoma Patients

• Kim JH
• Yu YS
• Khwarg SI
• Choi HS
• Shin HY
• Ahn HS

• KMID: 754340
• DOI: http://doi.org/10.3341/kjo.2003.17.1.35

Abstract

This study evaluated the effects of prolonged primary chemotherapy in retinoblastoma. The data for 27 eyes in 22 children who were treated for retinoblastoma with up to 13 cycles of primary chemotherapy was reviewed. The chemotherapy consisted of etoposide, vincristine, and either carboplatin or ifosfamide. In bilateral retinoblastoma, 1 eye was in each Ia, Ib, and Va, according to the Reese-Ellsworth classification, 2 in each IIa, IIIa, and IIIb, 4 in IIb, and 5 in IVa. Enucleation was performed in 1 in IIa and 1 in Va. In unilateral, 1 was in each IIa, IIIa, IVa, IVb, and Vb, and 4 in Va. Enucleation was performed in 8 with the exception of 1 in IIa. Complete regression was observed in 17 eyes (12 patients). There was no toxicity severe enough to delay treatment. Prolonged primary chemotherapy can be considered as an alternative treatment for retinoblastoma in III or less.

Keyword

cryotherapy; laser photocoagulation; prolonged primary chemotherapy; retinoblastoma

MeSH Terms

Antineoplastic Agents/administration& dosage
Antineoplastic Agents, Alkylating/administration& dosage
Antineoplastic Agents, Phytogenic/administration& dosage
Antineoplastic Combined Chemotherapy Protocols/*administration& dosage
Carboplatin/administration& dosage
Child, Preschool
Drug Administration Schedule
Etoposide/administration& dosage
Eye Enucleation
Human
Ifosfamide/administration& dosage
Infant
Retinal Neoplasms/*drug therapy/surgery/ultrasonography
Retinoblastoma/*drug therapy/surgery/ultrasonography
Retrospective Studies
Vincristine/administration& dosage