Korean J Radiol.  2001 Dec;2(4):192-196. 10.3348/kjr.2001.2.4.192.

Diffusion-Weighted MR Imaging in Biopsy-Proven Creutzfeldt-Jakob Disease

Affiliations
  • 1Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, SNUMRC, Seoul, Korea. changkh@radcom.snu.ac.kr
  • 2Department of Neurology, Seoul National University College of Medicine.

Abstract


OBJECTIVE
To compare conventional and diffusion-weighted MR imaging in terms of their depiction of the abnormalities occurring in Creutzfeldt-Jakob disease. MATERIALS AND METHODS: We retrospectively analyzed the findings of conventional (T2-weighted and fluid-attenuated inversion recovery) and diffusion-weighted MR imaging in four patients with biopsy-proven Creutzfeldt-Jakob disease. The signal intensity of the lesion was classified by visual assessment as markedly high, slightly high, or isointense, relative to normal brain parenchyma. RESULTS: Both conventional and diffusion-weighted MR images demonstrated bilateral high signal intensity in the basal ganglia in all four patients. Cortical lesions were observed on diffusion-weighted MR images in all four, and on fluid-attenuated inversion recovery MR images in one, but in no patient on T2-weighted images. Conventional MR images showed slightly high signal intensity in all lesions, while diffusion-weighted images showed markedly high signal intensity in most. CONCLUSION: Diffusion-weighted MR imaging is more sensitive than its conventional counterpart in the depiction of Creutzfeldt-Jakob disease, and permits better detection of the lesion in both the cerebral cortices and basal ganglia.

Keyword

Brain, infection; Creutzfeldt-Jakob disease; Dementia; Magnetic resonance (MR), diffusion study
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