Yonsei Med J.  2007 Jun;48(3):465-473. 10.3349/ymj.2007.48.3.465.

Analysis of Prognostic Factors and Treatment Modality Changes in Breast Cancer: A Single Institution Study in Korea

• Lee WS
• Lee JE
• Kim JH
• Nam SJ
• Yang JH

• KMID: 724102
• DOI: http://doi.org/10.3349/ymj.2007.48.3.465

Abstract

PURPOSE
To determine the effects of new breast cancer treatments and to provide a baseline for monitoring the development of breast cancer in Korean women, we conducted an analysis at our institution to determine long-term clinicopathological features, survival rates, and prognostic factors. MATERIALA AND METHODS: This study retrospectively analyzed 2,403 patients between Sep 1994 and Dec 2002, who underwent breast cancer surgery at Samsung Medical Center in Korea. Demographic data, pathologic records and surgical records were collected. RESULTS: After a median follow-up duration of 121.9 (range: 2-158.1) months, the 5-year disease free survival (DFS) was 82.8% and the 10-year DFS was 74.7%. The 5-year and 10-year overall survival (OS) rates were 89.4% and 82.9%, respectively. Using multivariate analyses, we determined that the nodal status (p < 0.001), angioinvasion (p < 0.001), positive PR (p < 0.001), and C-erb-B2 (p < 0.001) were independent prognostic factors for OS. The frequency of breast conserving surgery was 33.9% before Dec 1999, and increased up to 44.1% by year Dec 2002. CONCLUSION: Most of the prognostic variables and clinical characteristics of the Korean breast cancer patients were similar to those reported for Western populations. However, the age distribution in Korean patients seemed to be different from that in patients from Western countries.

Keyword

Breast cancer; survival; disease free survival; breast conserving surgery

MeSH Terms

Adult
Aged
Aged, 80 and over
Breast Neoplasms/mortality/pathology/*surgery
Female
Follow-Up Studies
Humans
Kaplan-Meiers Estimate
Korea
Mastectomy/*methods/statistics & numerical data
Mastectomy, Segmental/*methods/statistics & numerical data
Middle Aged
Multivariate Analysis
Prognosis
Proportional Hazards Models
Retrospective Studies
Survival Rate

Figure

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  Fig. 1 Overall survival from breast cancer at Samsung Medical Center.

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  Fig. 2 Disease-free survival from breast cancer at Samsung Medical Center.

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  Fig. 3 Overall survival according to TNM stage at Samsung Medical Center.

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  Fig. 4 Operative pattern changes at Samsung Medical Center.

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