Yonsei Med J.  1999 Oct;40(5):506-509. 10.3349/ymj.1999.40.5.506.

A case with intrahepatic double cancer: hepatocellular carcinoma and cholangiocarcinoma associated with multiple von Meyenburg complexes

• Kim YW
• Park YK
• Park JH
• Lee J
• Lee SM
• Hong SW
• Yang MH

• KMID: 711686
• DOI: http://doi.org/10.3349/ymj.1999.40.5.506

Abstract

Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) is sometimes found in resected livers, however, cases with double cancer of HCC and CC are very rare. As well, the rarity of CC arising in von Meyenburg complexes (VMCs) is appreciated. We report the case of a 74-year-old man found to have intrahepatic double cancer composed of well-differentiated HCC and CC which exhibited a histologic progression from VMCs to adenomatous lesions and CC. To our knowledge, this is the first case report published in the literature of a double HCC and CC associated with multiple VMCs. The pathogenesis and previous associated reports of these lesions are discussed.

Keyword

Double cancer; hepatocellular carcinoma; cholangiocarcinoma; von Meyenburg complex

MeSH Terms

Aged
Bile Ducts, Intrahepatic/abnormalities*
Carcinoma, Hepatocellular/pathology*
Carcinoma, Hepatocellular/etiology
Case Report
Cholangiocarcinoma/pathology*
Cholangiocarcinoma/etiology
HumanLiver Neoplasms/pathology*
Liver Neoplasms/etiology
Male
Neoplasms, Multiple Primary/pathology*
Neoplasms, Multiple Primary/etiology