Yonsei Med J.  1999 Aug;40(4):327-330. 10.3349/ymj.1999.40.4.327.

Effects of priming with pancuronium or rocuronium on intubation with rocuronium in children

• Lee SK
• Kim JR
• Bai SJ
• Shin YS
• Nam YT
• Cohen SP

• KMID: 711657
• DOI: http://doi.org/10.3349/ymj.1999.40.4.327

Abstract

Rocuronium is a non-depolarizing neuromuscular blocking agent which has a rapid onset and intermediate duration of action. The goal of this study was to compare the neuromuscular blocking actions of rocuronium with and without a priming dose of pancuronium or rocuronium in children. Thirty patients were randomly allocated into 3 groups. Ten patients received a single dose of 0.6 mg/kg rocuronium (Group I). The others received either 0.015 mg/kg pancuronium (Group II) or 0.06 mg/kg rocuronium (Group III) 3 minutes before an intubating dose of 0.54 mg/kg rocuronium was given. Neuromuscular blockade was measured via accelerographic response to single stimulations (1 Hz) of the ulnar nerve until maximal twitch depression was reached followed by train-of-four (TOF) stimuli (2 Hz) at 15 second intervals for the remainder of recovery. Groups were compared with regard to onset time, duration and recovery indices. The onset time and duration of block did not differ significantly between groups. However, the time to recovery in group II (24.5 +/- 9.9 min) was significantly prolonged compared to that in group I (12.7 +/- 3.1 min) or group III (12.7 +/- 3.9 min). We concluded that the use of rocuronium with a preceding dose of either pancuronium or rocuronium provided no advantage for intubation in children.

Keyword

Neuromuscular relaxants; rocuronium; pancuronium; onset time; priming principle

MeSH Terms

Androstanols/therapeutic use*
Child
Comparative Study
Drug Therapy, Combination
Female
Human
Intubation, Intratracheal*
Male
Neuromuscular Nondepolarizing Agents/therapeutic use*
Pancuronium/therapeutic use*
Time Factors