Yonsei Med J.  1998 Aug;39(4):390-394. 10.3349/ymj.1998.39.4.390.

A case with sarcomatoid hepatocellular carcinoma

• Han JH
• Park YN
• Jung WH
• Chi HS
• Park C

• KMID: 711574
• DOI: http://doi.org/10.3349/ymj.1998.39.4.390

Abstract

Hepatocellular carcinoma (HCC) with sarcomatous features is a rare neoplasm which has been found in only 1.8% of surgically resected HCC and has a higher incidence of metastasis than usual HCC. We recently experienced a case of sarcomatoid HCC removed from a 49-year-old man. A surgically resected liver revealed a well-defined grayish-white solid firm mass showing extensive central necrosis and infiltrative growth margin. Microscopically, the entire tumor was composed of pleomorphic spindle cells with prominent nucleoli and frequent mitosis. It showed a sinusoidal infiltrative growth pattern at the tumor-nontumor boundary. The tumor cells reacted positively with AE3 (high molecular cytokeratin) and Vimentin and reacted negatively with AE1 (low molecular cytokeratin), cytokeratin19, carcinoembryonic antigen, alpha-fetoprotein, Factor VIII, CD31 and CD68. The spindle-shaped tumor cells were considered to originate from hepatocyte rather than from bile duct epithelium or mesenchymal elements.

Keyword

Hepatocellular carcinoma; sarcomatoid; liver

MeSH Terms

Carcinoma/pathology*
Carcinoma/pathology*
Carcinoma, Hepatocellular/pathology*
Case Report
Human
Liver Neoplasms/pathology*
Male
Middle Age