Yonsei Med J.  1989 Jun;30(2):180-185. 10.3349/ymj.1989.30.2.180.

A Comprehensive Study of Immunological Abnormalities in Korean Hemophiliacs

• Kim KY
• Yang CH
• Kang SH
• Kim DS

• KMID: 693179
• DOI: http://doi.org/10.3349/ymj.1989.30.2.180

Abstract

To determine laboratory evidence suggesting immunological abnormalities in persons with hemophilia, we evaluated the immunological status of 75 Korean hemophiliacs, seronegative for human immunodeficiency virus (HIV) antibodies, who have been treated only with Korean factor VIII concentrates. From this study, it was shown that Korean hemophiliacs had decreased CD4 levels, increased CD8 levels, and decreased CD4:CD8 ratios. Diminished lymphocyte response to the mitogens, phytohemagglutinin and concanavalin A, and decreased natural killer cell activity were observed in the hemophiliacs. In addition, production of interleukin-II in the hemophiliacs was lower than in the healthy controls. The percentage of B lymphocytes was significantly reduced but the serum levels of immunoglobulin (Ig) G were elevated. However, the serum Ig A and Ig M levels were normal. This study demonstrated a high frequency of immunological abnormalities in HIV antibody negative Korean hemophiliacs treated only with domestic factor VIII concentrates.

Keyword

Hemophiliacs; immunological abnormalities; factor VIII concentrate therapy

MeSH Terms

Adolescent
Adult
Child
Factor VIII/therapeutic use
HIV Seropositivity/immunology
Hemophilia A/drug therapy/*immunology
Human
Korea
Lymphocyte Activation
Lymphocytes/immunology
Male
Middle Age
Support, Non-U.S. Gov't