Yonsei Med J.  1979 Dec;20(2):133-137. 10.3349/ymj.1979.20.2.133.

Isolation of Beta-Lactamase-producing Neisseria gonorrhoeae

  • 1Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea.
  • 2Department of Obstetrics-Gynecology1, Yonsei University College of Medicine, Seoul, Korea.


It is known that penicillinase-producing Neisseria gonorrhoeae (PPNG) are frequently found in South-East Asia and the infection does not respond to the recommended does of penicillin. N. gonorrhoeae cultures isolated during June 1977 to June 1979, from Yonsei Medical Center patients were tested for beta-lactamase production. Among the 127 isolates tested one was positive by the rapid iodometric method. The culture also gave a positive result by the method of Hodge et al. No zone of inhibition was observed when its susceptility was tested with a 10 unit penicillin disk. The patient who yielded the organism was a 51-year-old housewife living in Seoul. Neither she nor her husband had ever traveled abroad. This result documented the presence of PPNG in this community. In the future laboratories may require careful watch to detect further spreading of PPNG.

MeSH Terms

Gonorrhea/drug therapy
Neisseria gonorrhoeae/enzymology*
Neisseria gonorrhoeae/isolation & purification
Penicillins/therapeutic use
beta-Lactamases/isolation & purification*

Cited by  1 articles

Antimicrobial Resistance of Neisseria gonorrhoeae Isolated in Korea
Hyukmin Lee, Kyungwon Lee, Yunsop Chong
J Bacteriol Virol. 2012;42(1):9-16.    doi: 10.4167/jbv.2012.42.1.9.

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