Yonsei Med J.  1970 Jun;11(1):16-21. 10.3349/ymj.1970.11.1.16.

On the Effect of Morphine Hydrochloride on the Mesenteric Mast cells of Albino Rats

• Park MS
• Kang HS
• Pak SY
• Choi KD

• KMID: 687633
• DOI: http://doi.org/10.3349/ymj.1970.11.1.16

Abstract

Histological studies were carried out on the degranulation of mesenteric mast cells of white rats caused by injections of morphine and nalorphine hydrochloride intravenously and the following conclusions were obtained. 1. By the injection of morphine hydrochloride fairly significant degranulation of the mesenteric mast cell was observed. 2. In various experimental doses of morphine hydrochloride the cytological change of the degranulation was not proportional to the doses of it in cases given more than 12mg./kg. of body weight. 3. The degranulating effect of the mesenteric mast cell by the injection of morphine hydrochloride was significantly inhibited by an adrenalectomy.

MeSH Terms

Adrenalectomy
Animal
Male
Mast Cells/drug effects*
Mesentery/drug effects*
Morphine/antagonists & inhibitors
Morphine/pharmacology*
Nalorphine/pharmacology
Rats