J Korean Med Sci.  2001 Dec;16(6):751-755. 10.3346/jkms.2001.16.6.751.

Is Tumor Necrosis Factor Genotype (TNFA2/TNFA2)a Genetic Prognostic Factor of an Unfavorable Outcome in IgA Nephropathy?

• Lee EY
• Yang DH
• Hwang KY
• Hong SY

• KMID: 648357
• DOI: http://doi.org/10.3346/jkms.2001.16.6.751

Abstract

The purpose of this study was to examine whether there are the associations between TNF alpha and TNF beta gene polymorphisms and the development and progression of Ig A nephropathy (IgAN). A cross-sectional study on TNF alpha and TNF betagene polymorphisms by polymerase chain reaction with restriction fragment length poly-morphisms was performed on 76 patients with primary IgAN confirmed by renal biopsy and 100 healthy controls. The allele with G-->A substitution was designated as TNFA2 for the TNF alpha gene and TNFB2 for the TNF betagene. A patient in whom dialysis treatment was started or whose serum creatinine became double or over during the follow-up duration was designated as a "progressor". The TNFA2/ TNFA2 genotype was more prevalent in the progressor than in the non-pregressor group (20.0 vs 3.3%, p<0.05). Clinical factors such as serum creatinine, systolic and diastolic blood pressure (p<0.001, respectively) were higher and pathologic factor such as Grade IV or V renal lesions was more prevalent (p<0.01) in the progressor than in the non-progressor group. Therefore, TNFA2/TNFA2 genotype may be a risk factor for the progression of IgAN.

Keyword

Glomerulonephritis, IgA; Tumor Necrosis Factor; Polymorphism (Genetics)

MeSH Terms

Adult
Biopsy
Cross-Sectional Studies
Disease Progression
Female
Genotype
Glomerulonephritis, IGA/*genetics/pathology
Human
Lymphotoxin/*genetics
Male
Polymorphism, Restriction Fragment Length
Predictive Value of Tests
Prognosis
Tumor Necrosis Factor/*genetics