J Korean Med Sci.  2000 Apr;15(2):203-210. 10.3346/jkms.2000.15.2.203.

Effects of decreased cerebral perfusion pressure on cerebral hemodynamics, brain cell membrane function and energy metabolism during the early phase of experimental Escherichia coli meningitis in the newborn piglet

• Park WS
• Chang YS

• KMID: 648125
• DOI: http://doi.org/10.3346/jkms.2000.15.2.203

Abstract

In this study, we tested the hypothesis that decreased cerebral perfusion pressure (CPP) induces cerebral ischemia and worsen brain damage in neonatal bacterial meningitis. Meningitis was induced by intracisternal injection of 10(9) colony forming units of Escherichia coli in 21 newborn piglets. Although CPP decreased significantly at 8 hr after bacterial inoculation, deduced hemoglobin (HbD), measured as an index of changes in cerebral blood flow by near infrared spectroscopy, did not decrease significantly. In correlation analyses, CPP showed significant positive correlation with brain ATP and inverse correlation with brain lactate levels. CPP also correlated positively with HbD and oxidized cytochrome aa3 (Cyt aa3) by near infrared spectroscopy. However, CPP did not show significant correlation with cerebral cortical cell membrane Na+,K+-ATPase activity, nor with levels of lipid peroxidation products. In summary, decreased CPP observed in this study failed to induce cerebral ischemia and further brain injury, indicating that cerebrovascular autoregulation is intact during the early phase of experimental neonatal bacterial meningitis.

Keyword

Meningitis, Bacterial; Intracranial Pressure; Regional Blood Flow; Energy Metabolism; Animals, Newborn; Spectroscopy, Near Infrared

MeSH Terms

Animal
Animals, Newborn
Blood Glucose/metabolism
Cell Membrane/microbiology
Cell Membrane/enzymology
Cerebral Cortex/metabolism
Cerebral Cortex/chemistry
Cerebral Cortex/blood supply
Cerebrovascular Circulation/physiology*
Energy Metabolism/physiology*
Escherichia coli Infections/physiopathology*
Escherichia coli Infections/metabolism*
Glucose/cerebrospinal fluid
Glucose/analysis
Intracranial Pressure
Lactic Acid/cerebrospinal fluid
Lactic Acid/blood
Lactic Acid/analysis
Lipid Peroxidation/physiology
Meningitis, Bacterial/physiopathology*
Meningitis, Bacterial/metabolism*
Na(+)-K(+)-Exchanging ATPase/metabolism
Spectroscopy, Near-Infrared
Swine