J Korean Med Sci.  2000 Apr;15(2):189-193. 10.3346/jkms.2000.15.2.189.

Changes in biochemical bone markers during pregnancy and puerperium

• Yoon BK
• Lee JW
• Choi DS
• Roh CR
• Lee JH

• KMID: 648122
• DOI: http://doi.org/10.3346/jkms.2000.15.2.189

Abstract

To elucidate the changes in bone turnover during pregnancy and puerperium, we measured serially the levels of serum osteocalcin and urine deoxypyridinoline (Dpy) as markers of bone formation and bone resorption, respectively, in 22 healthy women with normal pregnancy. Nineteen non-pregnant women served as control. The Dpy levels increased significantly at 16 weeks of pregnancy and remained elevated thereafter. The levels of osteocalcin, however, were significantly decreased at 16 weeks of pregnancy and elevated later at 6 weeks postpartum. Bone turnover ratio (Dpy/osteocalcin) continued to rise during pregnancy, but returned to control levels 6 weeks after delivery. Dpy levels and bone turnover ratio during puerperium tended to be higher in 17 breast-feeding women than those of 5 exclusive bottle-feeders. In conclusion, bone resorption begins to increase from the second trimester of pregnancy and calcium release from bone tissue might play a major role in calcium homeostasis during the whole period of pregnancy as well as during lactation.

Keyword

Biological Markers; Pregnancy; Lactation; Disorder, Calcium Metabolism; Osteoporosis

MeSH Terms

Adult
Amino Acids/urine
Analysis of Variance
Biological Markers*
Bone Resorption/physiopathology*
Calcium/metabolism
Female
Human
Lactation/physiology
Osteocalcin/blood
Osteoporosis/physiopathology*
Pregnancy
Pregnancy Complications/physiopathology*
Puerperium/physiology*