J Korean Med Sci.  1999 Dec;14(6):675-678. 10.3346/jkms.1999.14.6.675.

99mTc-MIBI scan in mammary Pagets disease: a case report

• Han S
• Kim JS
• Kim BS
• Koh IH
• Park K

• KMID: 646046
• DOI: http://doi.org/10.3346/jkms.1999.14.6.675

Abstract

Technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) uptake is known to be increased in breast cancer because of increased blood flow from angiogenesis and heightened metabolism. We performed a 99mTc-MIBI scan in a patient with mammary Paget's disease. The patient had underlying invasive cancer in the same side of the breast. 99mTc-MIBI scan exhibited a scintigraphic image of the uptake from the invasive cancer lesion located deeply in the breast toward the epidermis. 99mTc-MIBI showed an uptake in the deeply located invasive cancer lesion as well as nipple lesion. Especially, the delayed phase of Tc-MIBI scan demonstrated the tumor site more accurately. In conclusion, 99mTc-MIBI scan could be a useful adjunct to clinical decision making in the management of Paget's disease of the breast.

Keyword

Breast; Paget's disease, mammary; Technetium Tc 99m Sestamibi; Diagnosis

MeSH Terms

Breast Neoplasms/radionuclide imaging*
Breast Neoplasms/pathology
Case Report
Female
Human
Middle Age
Nipples/pathology
Paget's Disease, Mammary/radionuclide imaging*
Paget's Disease, Mammary/pathology
Skin/pathology
Technetium Tc 99m Sestamibi/diagnostic use*