J Korean Med Sci.  1999 Oct;14(5):497-501. 10.3346/jkms.1999.14.5.497.

Augmented expression of cardiac atrial natriuretic peptide system in hypertensive rats

• An MR
• Chung YJ
• Kang DG
• Nam SC
• Lee JU

• KMID: 646016
• DOI: http://doi.org/10.3346/jkms.1999.14.5.497

Abstract

The present study was aimed at investigating the regulation of atrial natriuretic peptide (ANP) system in association with either enhanced or attenuated activity of the renin-angiotensin system (RAS). The cardiac tissue mRNA and peptide levels of ANP were measured in rats with two-kidney, one clip (2K1C) or deoxycorticosterone acetate (DOCA)-salt hypertension. Plasma renin concentration was increased in 2K1C hypertension along with increases of renin mRNA and protein contents in the clipped kidney. On the contrary, it was suppressed in DOCA-salt hypertension along with decreases of renin mRNA and protein contents in the remaining kidney. The plasma ANP concentration was similarly increased in both models of hypertension. The cardiac tissue ANP contents were not significantly changed, but the tissue ANP mRNA levels were upregulated in the hypertrophied heart in these two models of hypertension. It is suggested that the cardiac ANP system is transcriptionally enhanced by cardiac hypertrophy associated with hypertension, independent of the systemic RAS.

Keyword

Atrial natriuretic factor; Renin-Angiotensin system; Hypertension; Hypertrophy

MeSH Terms

Animal
Atrial Natriuretic Factor/metabolism*
Desoxycorticosterone
Gene Expression Regulation
Hypertension/metabolism*
Hypertension/chemically induced
Male
Myocardium/pathology
Organ Weight
Peptides
RNA, Messenger/analysis
Rats
Rats, Sprague-Dawley
Renin/genetics*
Renin/blood*
Renin-Angiotensin System/physiology