Diabetes Metab J.
2025 May;49(3):507-512. 10.4093/dmj.2024.0489.
Alpha-Tocopherol-Loaded Liposomes Reduce High Glucose Induced Oxidative Stress in Schwann Cells: A Proof of Concept Study
- Affiliations
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- 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
- 2Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea
- 3Department of Nano Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
- 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
- 5Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
- 6Department of Medical Device Development, Seoul National University College of Medicine, Seoul, Korea
- 7Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea
- KMID: 2567791
- DOI: http://doi.org/10.4093/dmj.2024.0489
Abstract
- Although oxidative stress is the main pathophysiology of the development of diabetic neuropathy, oral administration of antioxidants has given disappointing results. Here, we hypothesized that local delivery of antioxidants would provide protective effects on Schwann cells due to the high concentration of local lesions. We prepared alpha-tocopherol (ATF)-loaded liposomes and tested their skin penetration after sonication. An in vitro study using IMS-32 cells was conducted to determine the level of reactive oxygen species (ROS) scavenging effects of ATF-liposomes. ATF reduced ROS in high-glucose-exposed IMS-32 cells in a dosedependent manner. ATF-liposomes also reduced the ROS level in vitro and ultrasound irradiation enhanced delivery to the dermis in porcine ear skin. This study showed that it is feasible to deliver ATF through the skin and can effectively reduce ROS. This model is worthy of development for clinical use.
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