Korean J Blood Transfus.  2025 Apr;36(1):14-18. 10.17945/kjbt.2025.36.1.1 4.

Is Pre-Transfusion Antihistamine Administration Necessary?

• Lim YA

• KMID: 2566834
• DOI: http://doi.org/10.17945/kjbt.2025.36.1.1 4

Abstract

This study reviewed allergic transfusion reactions (ATRs) and the efficacy of pre-transfusion antihistamine (PreTAH) administration. Studies have shown that PreTAH does not prevent all ATRs and provides no significant benefit over non-administration groups. Instead, they may cause sedation, increase the burden on medical staff, and lack cost-effectiveness. Most transfused patients do not experience ATRs; except for anaphylaxis, they pose minimal risk. Thus, the decision to administer PreTAH should carefully weigh the benefits and risks. Routine PreTAH use in all transfusion patients is not recommended. Instead, PreTAH should be reserved for patients with a high risk of allergic reactions based on their medical history and risk factors.

Keyword

Blood transfusion; Adverse effects; Histamine H1 antagonist; Premedication