Prospective Multicenter Observational Study on Postoperative Quality of Life According to Type of Gastrectomy for Gastric Cancer

Oh, Sung Eun; Suh, Yun-Suhk; An, Ji Yeong; Ryu, Keun Won; Cho, In; Kim, Sung Geun; Park, Ji-Ho; Hur, Hoon; Kim, Hyung-Ho; Ahn, Sang-Hoon; Hwang, Sun-Hwi; Yoon, Hong Man; Park, Ki Bum; Kim, Hyoung-Il; Kwon, In Gyu; Yang, Han-Kwang; Suh , Byoung-Jo; Jeong, Sang-Ho; Kim, Tae-Han; Kwon, Oh Kyoung; Ahn, Hye Seong; Park, Ji Yeon; Yoon , Ki Young; Son, Myoung Won; Kong, Seong-Ho; Son, Young-Gil; Song, Geum Jong; Yun, Jong Hyuk; Bae, Jung-Min; Park, Do Joong; Lee, Sol; Yang, Jun-Young; Seo, Kyung Won; Jang, You-Jin; Kang, So Hyun; Eom, Bang Wool; Lee, Joongyub; Lee, Hyuk-Joon; ,

J Gastric Cancer. 2025 Apr;25(2):382-399. 10.5230/jgc.2025.25.e26.

Prospective Multicenter Observational Study on Postoperative Quality of Life According to Type of Gastrectomy for Gastric Cancer

Oh SE ¹
Suh YS ²
An JY ¹
Ryu KW ³
Cho I ⁴
Kim SG ⁵
Park JH ⁶
Hur H ⁷
Kim HH ²
Ahn SH ²
Hwang SH ⁸
Yoon HM ³
Park KB ⁹
Kim HI ¹⁰
Kwon IG ¹¹
Yang HK ¹²
Suh BJ¹³
Jeong SH ¹⁴
Kim TH ¹⁴
Kwon OK ⁹
Ahn HS ¹⁵
Park JY ⁹
Yoon KY¹⁶
Son MW ¹⁷
Kong SH ¹²
Son YG ¹⁸
Song GJ ¹⁷
Yun JH ¹⁷
Bae JM ¹⁹
Park DJ ¹²
Lee S ²⁰
Yang JY ²¹
Seo KW ¹⁶
Jang YJ ²²
Kang SH ²
Eom BW ³
Lee J ²³
Lee HJ ¹²
on behalf of the Korean Quality of Life in Stomach Cancer Patients Study (KOQUSS) Group

Affiliations

¹Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
²Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea
³Center for Gastric Cancer, National Cancer Center, Goyang, Korea
⁴Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
⁵Department of Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
⁶Department of Surgery, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea
⁷Department of Surgery, Ajou University School of Medicine, Suwon, Korea
⁸Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
⁹Department of Surgery, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea
¹⁰Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
¹¹Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
¹²Department of Surgery and Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
¹³Department of Surgery, Inje University Haeundae Paik Hospital, Busan, Korea
¹⁴Department of Surgery, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea
¹⁵Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea
¹⁶Department of Surgery, Kosin University College of Medicine, Busan, Korea
¹⁷Department of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
¹⁸Department of Surgery, Keimyung University Dongsan Medical Center, Daegu, Korea
¹⁹Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea
²⁰Department of Surgery, Seoul Medical Center, Seoul, Korea
²¹Department of Surgery, Gachon University Gil Medical Center, Incheon, Korea
²²Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
²³Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea

KMID: 2566761
DOI: http://doi.org/10.5230/jgc.2025.25.e26

Abstract

Purpose
This study evaluated the postoperative quality of life (QoL) after various types of gastrectomy for gastric cancer.
Materials and Methods
A multicenter prospective observational study was conducted in Korea using the Korean Quality of Life in Stomach Cancer Patients Study (KOQUSS)-40, a new QoL assessment tool focusing on postgastrectomy syndrome. Overall, 496 patients with gastric cancer were enrolled, and QoL was assessed at 5 time points: preoperatively and at 1, 3, 6, and 12 months after surgery.
Results
Distal gastrectomy (DG) and pylorus-preserving gastrectomy (PPG) showed significantly better outcomes than total gastrectomy (TG) and proximal gastrectomy (PG) with regard to total score, indigestion, and dysphagia. DG, PPG, and TG also showed significantly better outcomes than PG in terms of dumping syndrome and worry about cancer. Postoperative QoL did not differ significantly according to anastomosis type in DG, except for Billroth I anastomosis, which achieved better bowel habit change scores than the others. No domains differed significantly when comparing double tract reconstruction and esophagogastrostomy after PG. The total QoL score correlated significantly with postoperative body weight loss (more than 10%) and extent of resection (P<0.05 for both). Reflux as assessed by KOQUSS-40 did not correlate significantly with reflux observed on gastroscopy 1 year postoperatively (P=0.064).
Conclusions
Our prospective observation using KOQUSS-40 revealed that DG and PPG lead to better QoL than TG and PG. Further study is needed to compare postoperative QoL according to anastomosis type in DG and PG.

Keyword

Stomach neoplasm; Quality of life; Survey and questionnaire; Gastrectomy

Prospective Multicenter Observational Study on Postoperative Quality of Life According to Type of Gastrectomy for Gastric Cancer

Abstract

Keyword

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