Psychiatry Investig.
2025 Apr;22(4):424-434. 10.30773/pi.2024.0336.
Pre-Treatment Perceived Social Support Is Associated With Chemotherapy-Induced Peripheral Neuropathy in Patients With Breast Cancer: A Longitudinal Study
- Shin JS
1,2 - Jung S2
- Won GH3
- Lee SH1,2
- Kim J4
- Jung S5
- Yeom CW6
- Lee KM7
- Son KL8
- Kim Ji9
- Jeon SY10
- Lee HB9,11,12
- Hahm BJ1,2,13
- Affiliations
-
- 1Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
- 2Department of Psychiatry and Behavioral Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
- 3Department of Psychiatry, Chungnam National University Sejong Hospital, Sejong, Republic of Korea
- 4Department of Medicine, The Central Force for National Defence, Republic of Korea Army Personnel Command, Yongin, Republic of Korea
- 5Department of Psychiatry, Korea University Ansan Hospital, Ansan, Republic of Korea
- 6Department of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Republic of Korea
- 7Mind Lab the Place Psychiatric Clinic, Seoul, Republic of Korea
- 8Department of Psychiatry, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
- 9Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea
- 10Department of Surgery, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea
- 11Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
- 12Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
- 13Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea
- KMID: 2566736
- DOI: http://doi.org/10.30773/pi.2024.0336
Abstract
Objective
Previous studies have reported an association between cancer-related symptoms and perceived social support (PSS). The objective of this study was to analyze whether Chemotherapy-Induced Peripheral Neuropathy (CIPN), a prevalent side effect of chemotherapy, varies according to PSS level using a validated tool for CIPN at prospective follow-up.
Methods
A total of 39 breast cancer patients were evaluated for PSS using the Multidimensional Scale of Perceived Social Support (MSPSS) prior to chemotherapy and were subsequently grouped into one of two categories for each subscale: low-to-moderate PSS and high PSS. CIPN was prospectively evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20 (CIPN20) at five time points. A linear mixed-effects model with square root transformation was employed to investigate whether the CIPN20 scales varied by PSS level and time point.
Results
Statistical analysis of the MSPSS total scale and subscales revealed a significant effect of the friends subscale group and time point on the CIPN20 sensory scale. The sensory scale score of CIPN20 was found to be lower in participants with high PSS from friends in comparison to those with low-to-moderate PSS at 1 month post-chemotherapy (p=0.010).
Conclusion
This is the first study to prospectively follow the long-term effect of pre-treatment PSS from friends on CIPN. Further studies based on larger samples are required to analyze the effects of PSS on the pathophysiology of CIPN.
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