Ann Clin Nutr Metab.  2025 Apr;17(1):66-74. 10.15747/ACNM.25.001.

Perioperative outcomes of older adult patients with pancreatic cancer based on nutritional status: a retrospective cohorat study

• Morikawa T
• Ishida M
• Mizuma M
• Nakagawa K
• Kamei T
• Unno M

• KMID: 2566724
• DOI: http://doi.org/10.15747/ACNM.25.001

Abstract

Purpose
This study investigated the effects of preoperative nutritional status on postoperative outcomes in older adult patients with pancreatic adenocarcinoma.
Methods
The background and perioperative factors of patients who underwent pancreatectomy for pancreatic adenocarcinoma between 2007 and 2020 were retrospectively analyzed.
Results
Patients aged 75 years or over (older adults) were significantly associated with hypertension, upfront surgery, and lower prognostic nutritional index. In addition, these patients had a significantly lower rate of portal vein resection, less blood loss, and shorter operation time than patients aged less than 75 years (non-older adults). During the postoperative course, older adult patients had a higher rate of pneumonia and lower overall survival than younger patients, although recurrence‐free survival was comparable. In addition, older adult patients showed preoperative malnutrition as a risk factor for postoperative in‐hospital death.
Conclusion
Surgical treatment for pancreatic cancer in older adult patients was performed safely. However, preoperative malnutrition is a risk factor for in‐hospital death and such patients require nutritional support and less‐invasive surgery.

Keyword

Aged; Nutritional status; Pancreatectomy; Pancreatic neoplasm; Prognosis