Korean J Radiol.
2025 Mar;26(3):246-268. 10.3348/kjr.2024.0982.
A Radiologist’s Guide to IDH-Wildtype Glioblastoma for Efficient Communication With Clinicians: Part I–Essential Information on Preoperative and Immediate Postoperative Imaging
- Vollmuth P
1,2,3 - Karschnia P4,5
- Sahm F6,7
- Park YW8
- Ahn SS8
- Jain R9,10
- Affiliations
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- 1Division for Computational Radiology & Clinical AI (CCIBonn.ai), Clinic for Neuroradiology, University Hospital Bonn, Bonn, Germany
- 2Medical Faculty Bonn, University of Bonn, Bonn, Germany
- 3Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany
- 4Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany
- 5Department of Neurosurgery, Friedrich-Alexander-University University, Erlangen-Nuremberg, Germany
- 6Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany
- 7Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
- 8Department of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Republic of Korea
- 9Department of Radiology, New York University Grossman School of Medicine, New York, USA
- 10Department of Neurosurgery, New York University Grossman School of Medicine, New York, USA
- KMID: 2565608
- DOI: http://doi.org/10.3348/kjr.2024.0982
Abstract
- The paradigm of isocitrate dehydrogenase (IDH)-wildtype glioblastoma is rapidly evolving, reflecting clinical, pathological, and imaging advancements. Thus, it remains challenging for radiologists, even those who are dedicated to neuro-oncology imaging, to keep pace with this rapidly progressing field and provide useful and updated information to clinicians. Based on current knowledge, radiologists can play a significant role in managing patients with IDH-wildtype glioblastoma by providing accurate preoperative diagnosis as well as preoperative and postoperative treatment planning including accurate delineation of the residual tumor. Through active communication with clinicians, extending far beyond the confines of the radiology reading room, radiologists can impact clinical decision making. This Part 1 review provides an overview about the neuropathological diagnosis of glioblastoma to understand the past, present, and upcoming revisions of the World Health Organization classification. The imaging findings that are noteworthy for radiologists while communicating with clinicians on preoperative and immediate postoperative imaging of IDH-wildtype glioblastomas will be summarized.
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