Korean Circ J.  2025 Feb;55(2):118-120. 10.4070/kcj.2024.0377.

Is Shank3 a ‘Friend or Foe’ of the Heart? Its Role in Cardiac Calcium Homeostasis

• Kim HK
• Han J

• KMID: 2565416
• DOI: http://doi.org/10.4070/kcj.2024.0377

Figure

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  Figure 1 Effects of Shank3 overexpression on cardiac dysfunction. Overexpression of Shank3 in mice leads to hypercontractility and cardiac fibrosis through dysregulation of calcium signaling and a reduction in troponin I. These functional changes result in heart failure and early mortality in the animals.LT Ca2+ = L-type Calcium ion; Shank3 = SH3 and multiple ankyrin repeat domains 3; TG = = Shank3 transgenic mouse; WT = wild type mouse.

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