Int J Stem Cells.  2025 Feb;18(1):12-20. 10.15283/ijsc23173.

Crosstalk between Signaling Pathways and Energy Metabolism in Pluripotency

• Kim KT
• Kim SM
• Cha HJ

• KMID: 2565193
• DOI: http://doi.org/10.15283/ijsc23173

Abstract

The sequential change from totipotency to multipotency occurs during early mammalian embryo development. However, due to the lack of cellular models to recapitulate the distinct potency of stem cells at each stage, their molecular and cellular characteristics remain ambiguous. The establishment of isogenic naïve and primed pluripotent stem cells to represent the pluripotency in the inner cell mass of the pre-implantation blastocyst and in the epiblast from the post-implantation embryo allows the understanding of the distinctive characteristics of two different states of pluripotent stem cells. This review discusses the prominent disparities between naïve and primed pluripotency, including signaling pathways, metabolism, and epigenetic status, ultimately facilitating a comprehensive understanding of their significance during early mammalian embryonic development.

Keyword

Naïve pluripotent stem cells; Primed pluripotent stem cells; Signaling pathways; Cellular metabolism; Early embryo development; Pluripotent stem cells