J Neurogastroenterol Motil.  2025 Jan;31(1):95-101. 10.5056/jnm24070.

Association Between Functional Dyspepsia and Binge Eating Disorder: A Frequent, Often Overlooked Overlap Clinical Presentation

• Félix-Téllez FA
• Cruz-Salgado AX
• Remes-Troche JM
• Flores-Rendon
• Ordaz-Álvarez HR
• Velarde-Ruiz Velasco JA
• Flores-Lizárraga MAO
• Soto-González JI
• Abizaid-Herrera NS

• KMID: 2564648
• DOI: http://doi.org/10.5056/jnm24070

Abstract

Background/Aims
This study aims to investigate the association between Binge Eating Disorder and functional dyspepsia in a Mexican population, focusing on symptomatology and demographic characteristics.
Methods
We conducted a cross-sectional study on 1016 subjects, evaluating binge eating disorder (BED) and functional dyspepsia based on the Rome IV criteria. Data collection included sociodemographic information, gastrointestinal symptom severity, and anxiety/depression screening using validated tools. A multivariate logistic regression analysis with the ² test was conducted for comparison analysis.
Results
The prevalence of dyspepsia in BED was 53.6% (95% CI, 46-56). Postprandial fullness (OR, 1.52; 95% CI, 1.06-2.17; P = 0.021) and overlap syndrome (OR, 1.80; 95% CI, 1.25-2.60; P = 0.002) were significantly associated with BED. Patients with BED also presented more severe postprandial distress syndrome (P = 0.027). Anxiety was prevalent in BED patients, while depression was more prominent in patients with BED and dyspepsia overlap.
Conclusions
BED patients have a high prevalence of dyspepsia with an association between postprandial fullness and this eating disorder. BED appears to be more prevalent in younger individuals and males. These findings underscore the importance of considering dyspepsia in the management of BED and highlight the need for further research on this association.

Keyword

Dyspepsia; Feeding and eating disorders; Gastrointestinal diseases