Med Lasers.  2024 Dec;13(4):185-194. 10.25289/ML.24.036.

Photobiomodulation as a novel therapeutic approach in the management of atopic diseases

• Woo K
• Padalhin A

• KMID: 2564467
• DOI: http://doi.org/10.25289/ML.24.036

Abstract

Hypersensitivities such as asthma, eczema, and allergic rhinitis, are chronic conditions marked by inflammation and immune system dysfunction. These conditions pose significant health challenges, often leading to an impaired quality of life. Although traditional therapies focus primarily on symptom management, they frequently come with substantial side effects. Photobiomodulation (PBM), a non-invasive treatment involving low-level light therapy, has emerged as a promising alternative. PBM offers a multifaceted approach to addressing the underlying mechanisms of atopic diseases by targeting the key immune pathways, including cytokine production, mast cell stabilization, and T cell modulation. Numerous experimental studies have revealed the therapeutic potential of PBM in various atopic disease models. These findings suggest that PBM may offer a safe and effective adjunct or alternative therapy for individuals suffering from these conditions. Nevertheless, further clinical research is essential to optimize the treatment parameters and fully unlock the therapeutic benefits of PBM. A deeper understanding of PBM’s molecular mechanisms will elucidate its precise mode of action. This can pave the way for the development of targeted therapies that maximize efficacy while minimizing the potential side effects. Ultimately, PBM may revolutionize the management of atopic diseases, offering a more holistic and patient-centered approach to treatment.

Keyword

Hypersensitivity; Allergy; Therapy; Photobiomodulation