Med Lasers.  2024 Jun;13(2):71-74. 10.25289/ML.24.018.

Exploring the intersection of laser technology and neutropenia: mechanisms, impacts, and mitigation strategies

• Ryu HS

• KMID: 2564452
• DOI: http://doi.org/10.25289/ML.24.018

Abstract

Laser technology, characterized by its precision and high-intensity applications, is being used increasingly in medical treatments, ranging from oncology to dermatology and ophthalmology. Neutropenia, a hematological condition marked by a critically low neutrophil count, presents significant clinical challenges because of its association with increased infection risk. This review explores the intricate relationship between laser technology and neutropenia, emphasizing the mechanisms through which laser treatments can induce neutropenia, their clinical implications, and strategies for mitigation. High-intensity laser therapies, such as photodynamic therapy, can generate systemic inflammatory responses and oxidative stress, potentially impairing the bone marrow function and reducing neutrophil production. Clinically, managing the risk of neutropenia involves pre-treatment evaluation, continuous monitoring of blood counts, and prophylactic measures such as granulocyte colony-stimulating factor. Recent advancements, including the development of selective photosensitizers and personalized treatment protocols, show promise in enhancing the safety and efficacy of laser treatments. This review underscores the need for comprehensive patient management and ongoing research to balance the therapeutic benefits of laser technology with potential hematological risks, ultimately aiming to optimize patient outcomes while minimizing the adverse effects.

Keyword

Laser; Neutropenia; Neutrophils; Immunosuppression; Mitigation strategies