Ann Lab Med.  2025 Jan;45(1):105-108. 10.3343/alm.2024.0216.

Endogenous Thrombin Potential Level Helps Predict High Blood Loss in Patients Undergoing Cardiac Surgery

• Jung Y
• Choi JW
• Hwang HY
• Gu JY
• Kim KH
• Kim HK

• KMID: 2563863
• DOI: http://doi.org/10.3343/alm.2024.0216

Figure

• 

  Fig. 1 Comparison of TGA results between the low- (N=45) and high- (N=44) blood-loss groups. (A) ETP, (B) lag time, (C) peak height, and (D) start tail. The groups were compared using independent t-tests, and only significant results (*P<0.05) are shown. Abbreviations: TGA, thrombin generation assay; ETP, endogenous thrombin potential; T0, pre-surgery; T1, immediately post-surgery; T2, 1 day post-surgery; T3, 3 days post-surgery.

Reference

References

1. Whitlock R, Crowther MA, Ng HJ. 2005; Bleeding in cardiac surgery: its prevention and treatment-an evidence-based review. Crit Care Clin. 21:589–610. DOI: 10.1016/j.ccc.2005.04.003. PMID: 15992674.

2. Karkouti K, Wijeysundera DN, Yau TM, Beattie WS, Abdelnaem E, McCluskey SA, et al. 2004; The independent association of massive blood loss with mortality in cardiac surgery. Transfusion. 44:1453–62. DOI: 10.1111/j.1537-2995.2004.04144.x. PMID: 15383018.

3. Christensen MC, Dziewior F, Kempel A, von Heymann C. 2012; Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery. J Cardiothorac Vasc Anesth. 26:46–51. DOI: 10.1053/j.jvca.2011.09.021. PMID: 22100857.

4. Sharma S, Kumar S, Tewari P, Pande S, Murari M. 2018; Utility of thromboelastography versus routine coagulation tests for assessment of hypocoagulable state in patients undergoing cardiac bypass surgery. Ann Card Anaesth. 21:151–7. DOI: 10.4103/aca.ACA_174_17. PMID: 29652276. PMCID: PMC5914215.

5. Kawahara Y, Ohtsuka K, Tanaka K, Yamanaka M, Kamiya H, Kunisawa T, et al. 2021; Use of laboratory testing for prediction of postoperative bleeding volume in cardiovascular surgery. Thromb J. 19:70. DOI: 10.1186/s12959-021-00324-4. PMID: 34627290. PMCID: PMC8501637. PMID: 292e2e1071904a7c87af2cb78e8b9e3d.

6. Coakley M, Hall JE, Evans C, Duff E, Billing V, Yang L, et al. 2011; Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding. J Thromb Haemost. 9:282–92. DOI: 10.1111/j.1538-7836.2010.04146.x. PMID: 21091865.

7. Lim HJ, Jang H, Lee N, Jeong E, Park Y, Jo Y, et al. 2024; Prediction of Mid-term Platelet Transfusion in Stable Trauma Patients Using Rotational Thromboelastometry. Ann Lab Med. 44(1):74–81. DOI: 10.3343/alm.2024.44.1.74. PMID: 37665288. PMCID: PMC10485857.

8. Jeong D, Kim SY, Gu JY, Kim HK. 2022; Assessment of rotational thromboelastometry and thrombin generation assay to identify risk of high blood loss and re-operation after cardiac surgery. Clin Appl Thromb Hemost. 28:1–7. DOI: 10.1177/10760296221123310. PMID: 36124381. PMCID: PMC9490460. PMID: 904f71b17a7442d486c3f20949002b8e.

9. Chee YL, Crawford JC, Watson HG, Greaves M. 2008; Guidelines on the assessment of bleeding risk prior to surgery or invasive procedures. British Committee for Standards in Haematology. Br J Haematol. 140:496–504. DOI: 10.1111/j.1365-2141.2007.06968.x. PMID: 18275427.