World J Mens Health.  2025 Jan;43(1):28-40. 10.5534/wjmh.230145.

The Role of Autophagy in Erectile Dysfunction

• Wu C
• Xiong Y
• Fu F
• Zhang F
• Qin F
• Yuan J

• KMID: 2563257
• DOI: http://doi.org/10.5534/wjmh.230145

Abstract

Autophagy is a conservative lysosome-dependent material catabolic pathway, and exists in all eukaryotic cells. Autophagy controls cell quality and survival by eliminating intracellular dysfunction substances, and plays an important role in various pathophysiology processes. Erectile dysfunction (ED) is a common male disease. It is resulted from a variety of causes and pathologies, such as diabetes, hypertension, hyperlipidemia, aging, spinal cord injury, or cavernous nerve injury caused by radical prostatectomy, and others. In the past decade, autophagy has begun to be investigated in ED. Subsequently, an increasing number of studies have revealed the regulation of autophagy contributes to the recovery of ED, and which is mainly involved in improving endothelial function, smooth muscle cell apoptosis, penile fibrosis, and corpus cavernosum nerve injury. Therefore, in this review, we aim to summarize the possible role of autophagy in ED from a cellular perspective, and we look forward to providing a new idea for the pathogenesis investigation and clinical treatment of ED in the future.

Keyword

Apoptosis; Autophagy; Endothelial cells; Erectile dysfunction; Fibrosis; Smooth muscle