Anat Biol Anthropol.  2024 Jun;37(2):113-120. 10.11637/aba.2024.37.2.113.

Collagen 24A1, a Potential Prognostic Biomarker in Hepatocellular Carcinoma

• Kim HR
• Kim J

• KMID: 2562485
• DOI: http://doi.org/10.11637/aba.2024.37.2.113

Abstract

The prognostic value of collagen 24A1 (COL24A1) and its association with tumor-infiltrating immune cells (TIICs) in hepatocellular carcinoma (HCC) remains unexplored. In this study, we aimed to evaluate the prognostic value of COL24A1 in HCC via comprehensive web database analysis such as various online databases, including the Tumor Immune Estimation Resource (TIMER), The University of ALabama at Birmingham CANcer data analysis, Kaplan-Meier plotter, and Gene Expression Profiling Interactive Analysis. COL24A1 mRNA expression was found to be upregulated in HCC as compared to that in normal tissues, which was associated with poor prognosis in HCC. Further, COL24A1 expression correlated positively with TIICs, including B cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells, which was also associated with poor prognosis in HCC. The TIMER database revealed positive correlations between COL24A1 expression and that of other collagen family members, including, COL1A1, COL5A1, COL16A1 and COL21A1 in HCC. Our findings demonstrate that COL24A1 may potentially serve as a prognostic biomarker in patients with HCC.

Keyword

Hepatocellular carcinoma; Collagen 24A1; Prognosis; Biomarker; Immune cells