Anat Biol Anthropol.  2023 Sep;36(3):111-126. 10.11637/aba.2023.36.3.111.

C4orf46 is a Potential Prognostic Biomarker for Liver Hepatocellular Carcinoma

• Kim HR
• Kim J

• KMID: 2549053
• DOI: http://doi.org/10.11637/aba.2023.36.3.111

Abstract

Chromosome 4 includes genetic factors involved in various cancers, such as liver hepatocellular carcinoma (LIHC), and those related to the diagnostic biomarkers of human diseases. However, chromosome 4 open-reading frame 46 (C4orf46), a part of chromosome 4, has not yet been evaluated as an LIHC biomarker. In this study, we investigated the potential of C4orf46 as a prognostic biomarker for LIHC and analyzed its correlations with immune cells and molecular functions. Data analysis using open online databases, including the Tumor Immune Estimation Resource, University of ALabama at Birmingham CANcer, Kaplan-Meier plotter, LinkedOmics, and Gene Expression Profiling Interactive Analysis version 2, revealed that C4orf46 was highly expressed in LIHC tissues than in normal tissues. Moreover, survival rate analyses, such as disease-specific, overall, progression-free, and relapse-free survival analyses, revealed that high expression of C4orf46 was associated with a poor prognosis in LIHC. C4orf46 expression was positively correlated with various tumorinfiltrating immune cells, including B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells. C4orf46 was also involved in chromosome segregation, DNA replication, cell cycle G2/M phase transition, and microtubule cytoskeleton organization during mitosis, mitotic cell cycle phase transition, and cell cycle checkpoints. In conclusion, C4orf46 is a potential prognostic biomarker that is correlated with immune infiltration in LIHC.

Keyword

Liver hepatocellular carcinoma; C4orf46; Prognosis; Biomarker