J Korean Ophthalmol Soc.  2024 Dec;65(12):810-815. 10.3341/jkos.2024.65.12.810.

Iris Metastasis of Non-small-cell Lung Cancer Inducing Anterior Uveitis and Secondary Glaucoma

• Moon JY
• In JH
• Cho IH

• KMID: 2562418
• DOI: http://doi.org/10.3341/jkos.2024.65.12.810

Abstract

Purpose
To report an iris metastasis of non-small-cell lung cancer inducing anterior uveitis and secondary glaucoma.
Case summary
A 63-year-old woman presented to our hospital with vision impairment and pain in her right eye. She had been receiving systemic chemotherapy and radiation therapy to manage non-small-cell lung cancer for 2 years. Her best-corrected visual acuities were 25/40 oculus dexter (OD) and 20/25 oculus sinister; intraocular pressure was 52 mmHg OD. Slit-lamp examination revealed multiple round iris nodules and a 1+ inflammatory response in the anterior chamber of the right eye. Despite the maximimal tolerated medical therapy and laser trabeculotomy, the intraocular pressure was not controlled. Because iris metastasis of non-small-cell lung cancer was suspected, aqueous humor cytology and iris tissue biopsy were performed. Cytological analysis did not reveal malignant cells, but histopathological examination confirmed iris metastasis of non-small-cell lung cancer. A restaging procedure for lung cancer was performed, revealing new findings of lung and pelvic bone metastasis.
Conclusions
Through histopathological examination, it is possible to confirm iris metastasis of malignant tumors. Op

Keyword

Neoplasm metastasis, Non-small cell lung carcinoma, Pathology